Senior Research Associate

Manager: Scientist III
Department: Research - Neuroscience
Location: Richmond, CA

Sangamo Therapeutics is a genomic medicine company building value with cutting-edge work across four distinct but complementary technology platforms – gene therapy, cell therapy, in vivo genome editing, and in vivo genome regulation. Using its deep scientific expertise and proprietary zinc finger genome engineering technology, Sangamo is working to create genomic cures for patients suffering from severe genetic diseases for which today’s medicines can only treat symptoms. At Sangamo, we are passionate about transforming lives by building a robust, sustainable, differentiated, innovative, and high value genomic medicine pipeline that addresses patients with life-limiting conditions. Sangamo takes pride in being the first to edit endogenous human genes, first to treat patients with gene edited T cells, and first to treat patients with in vivo genome editing. Our top priority is to meet the needs of patients with commitment and compassion. Along with our commitment to science and to our patients, we also endeavor to create an inclusive environment that promotes and values diversity. Sangamo is a company where individuals can flourish, grow and develop their expertise.

We are seeking top talent to join our mission. Let’s build a better future together.

JOB SUMMARY:   
Sangamo Therapeutics is seeking a talented Research Associate for a new position in our Neuroscience team to support development of novel ZFP-TFs for the treatment of CNS diseases.  The successful candidate will work within the Neuroscience team and contribute to the development of novel CNS therapeutics. Key responsibilities will include performance of neuronal cell culture experiments, assay development, and screening for on- and off-target activity using mRNA and AAV transduction techniques to support lead candidate selection. The candidate will also be responsible for generation of data from in vivo studies to support advancement of CNS programs toward the clinic. The position requires adaptability, creativity, good written and verbal communication skills, as well as a capacity for constant innovation in pursuit of company goals. The environment is exciting and fast-paced, and offers the opportunity to work and publish at the cutting edge of genome engineering research and translational medicine.


ESSENTIAL FUNCTIONS: 

• Process animal tissue for RNA, DNA, and protein endpoints
• Perform in vitro experiments in primary and iPSC-derived neurons
• Perform chronic AAV expression studies in mammalian cell models
• Independently plan, execute, troubleshoot, and document laboratory procedures and experiments with rigor and great attention to detail
• Analyze experimental data and present results at internal meetings
• Share technical expertise with different research teams within the CNS group as required

EDUCATION, EXPERIENCE AND SKILLS REQUIREMENTS:

• B.S. or M.S. in molecular and/or cellular biology, biochemistry, neuroscience, bioengineering, chemical engineering, or related discipline
• 6+ years of relevant laboratory experience (8+ years with B.S.) in an academic research laboratory or biotechnology company
• Experience with neuronal cell culture, including transfection and AAV transduction
• Extensive experience with molecular biology and biochemical methods and techniques including RT-qPCR, ELISA, western blotting, and nucleic acid and protein isolation from mammalian cells and animal tissues
• Preferred candidates will be proficient in use of the Microsoft Office Suite and statistical analysis and graphing software (e.g. GraphPad Prism, SigmaPlot)

OTHER QUALIFICATIONS:

• Strong experiment design, problem-solving, and data analysis skills are desired
• Excellent collaboration, communication, and presentation skills
• Experience with high-throughput assays and automation preferred
• Experience with genomic medicine and CNS-related fields preferred

Sangamo is an equal opportunity employer
The above reflects management’s definition of essential functions for this position but does not restrict the tasks that may be assigned. The above duties are representative only; management may assign or reassign duties and responsibilities to this position at any time.

COVID-19

Sangamo requires all U.S. workers to be fully vaccinated against COVID-19 as of their start date.  This requirement is a condition of employment at Sangamo, and it applies regardless of location or classification of role.  If you are unable to receive the vaccine, you will have an opportunity to request a reasonable accommodation consistent with applicable laws. 

Note to External Recruiters: Please understand that we do not accept unsolicited resumes from any source other than from the candidates themselves. Any agency or independent recruiter must have a signed copy of our agency agreement before presenting candidates. Submission of unsolicited resumes without our signed agreement will not create any implied obligation on our part.