Intellia Therapeutics

Associate Director, RNA Chemistry

Cambridge, MA
Jan 24, 2022
Science/R&D, Chemistry
Required Education
Position Type
Full time

Why Join Intellia? 

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. 

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. 

We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.   

How you will Achieve More with Intellia:

Intellia Therapeutics, Inc. is seeking a highly skilled and motivated Associate Director to advance our guide synthesis capabilities and participate in developing innovative therapies for patients. You will provide subject matter expertise on internal oligonucleotide synthesis/purification. Additional role responsibilities include:

  • Provide technical oversight and guidance to improve processes

  • Troubleshoot and optimize oligonucleotide synthesis

  • Proactively evaluate new technologies, be versed with current literature, and implement new features and functionality into RNA platform

  • Deliver reproducible and impactful results under ambitious timelines, present results in cross-functional meetings to a broad audience, both internally and externally

  • Lead oligonucleotide design and innovation strategies to support preclinical programs

  • Assist in I.P. filings

  • Manage CROs and collaborate with academic partners for external studies

  • Work with senior management to expand the company’s R&D team

About You:

Do you have advanced knowledge of the design, synthesis, and purification of oligonucleotides? Our ideal candidate will have a successful track record of people management experience, plus experience with nucleic acid purification and chemistry, enzyme kinetics, and analytical characterization of biomolecules. If you have these qualifications, we encourage you to apply! Additional role requirements include:

  • Ph.D. degree with more than 5 years of experience

  • Prior experience with tech transfer oligos, biologics process highly desirable

  • Knowledge of key analytical testing of oligos is desirable

  • Strong communication skills, time management, and work ethic

Meet your future team:

Chemistry and Delivery Sciences team is a fun, energetic, and passionate group of individuals whose mission is to develop the chemical building blocks that enable curative therapies. You will report directly to Senior Director, Chemistry & Delivery Sciences. This hiring manager co-leads chemistry and delivery efforts to identify next-generation nucleic acid and delivery systems for future clinical programs. Given the breadth of work on this team, the candidate will have the opportunity to explore a wide range of nucleic acid modifications, the challenges in the synthesis & purification of long guides to support Intellia’s gene-editing pipeline. 

The team is currently working mostly onsite to execute workflows in a wet-lab environment. Therefore, we require the candidate to be currently local to Cambridge MA, or open to relocating.  While much of the day-to-day operations require wet-lab work, our team is focused on building not just technical expertise but fostering an environment for the growth of scientists interested in a career in biotech and chemistry.  If you join our team, you can expect to join a hardworking and collaborative environment. We look forward to fostering your skills, learning from your experiences, and building a larger team that will make a difference in patients' lives.


Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.