Senior Research Associate, MRNA Process Development

Why Join Intellia? 

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. 

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. 

We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.   

How you will Achieve More with Intellia:

 In this Senior Research Associate role, you will be responsible for building tools required for the development of novel mRNA synthetic and purification processes in support of our lead and future in vivo gene editing therapeutic candidates. To this end, you will leverage your biochemistry experiences and purification process to fully develop efficient tools in the downstream purification processes required for Nucleic Acids.

• You will help advance our gene editing candidates such as NTLA2001 into a commercial process

• Explore the broad spectrum of purification tools to develop and scale up next generation nucleic acid therapeutics in support of Intellia’s platform technologies

• Design and perform process characterization studies (with some guidance), e.g. enzymatic reactions, Tangential Flow filtration (TFF, UF/DF), using DOE approaches and analyze experimental data

• Investigate new purification technologies, e.g. chromatography and filtration, to enhance product purity and process robustness

• Provide high quality Electronic Lab Notebook (ELN) documentations. Author and review technical reports

• Assist in technology transfers to CDMOs

• Operate and maintain multiple laboratory instruments. Assist in maintaining general laboratory functionality and supplies

About You:

 As an ideal candidate for this role, you have worked in process development or manufacturing science teams to develop late-stage manufacturing processes for large molecule drug substances or cell therapeutics. Additionally, you have experience working with oligonucleotides (RNAs/ DNAs) and understand basic biochemistry principles and analytical techniques necessary to characterize the product and impurities. Most importantly, if you have an enthusiast curiosity to develop mRNA processes and learn about the future of medicine in gene editing, then we encourage you to apply! Additional role requirements include:

• Proven record of successfully planning and executing lab experiments and projects.

• Lab experience in purification of DNA/RNA and/or proteins using TFF and/or column chromatography.

• Ability to multitask and handle a diverse array of challenges within a dynamic team environment

• Bachelor’s or Masters degree in Biochemistry, Biochemical Engineering, Chemical Engineering, or related field with 2+ years work experience

Meet your future team:

The Nucleic Acid Process Sciences team is a fun and energetic team of scientists focused on the internal development of nucleic acid therapeutics to create the curative gene editing technologies of the future. As a team, we drive the late-stage development of Intellia’s mRNA DS for Intellia’s lead programs. Furthermore, we are responsible for the development of enzymatic process and characterization tools to build a wide range of nucleic acid modalities for Intellia’s next generation platform technologies. We have an interesting and diverse background and set of experiences reflecting the breadth and depth of our responsibilities, and we look forward to meeting and welcoming onboard the next member of the team!

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Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.