Scientist 2, Assay Biology

Location
Hayward, California
Posted
Jan 23, 2022
Ref
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Required Education
Associate Degree
Position Type
Full time

Company Description

Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders who pioneered the field of single-molecule live cell imaging (Nobel Prize, 2014).

We are building a passionate and creative team eager to apply their talents to empower interdisciplinary scientific exploration, inaugurate a radical drug-discovery paradigm and ultimately create novel medicines. 

Position 

As a Scientist II in the Assay Biology Department, you will be an essential part of an interdisciplinary team of highly creative and talented individuals with outstanding expertise in the Company’s core platform technologies and drug discovery processes.  You’ll play a key role in developing cell-based assays and screening compounds to advance the research pipeline for multiple drug discovery programs. You’ll be collaborating and working closely with a team of biologists, chemists, and engineering experts.

About you:

  • You’re a rigorous cell biologist who takes pride in your ability to execute at the bench.
  • You enjoy teaching and mentoring research associates and are interested in helping build the Assay Biology group at Eikon.
  • You’re passionate about drug discovery and the goal of developing novel treatments for patients.
  • You’re conscientious, detail oriented, and organized.
  • You’re collaborative by nature and are happy to help.
  • You thrive in a fast-paced environment and enjoy pushing the edge of what is possible. 

What you’ll do:

  • Develop, troubleshoot, and optimize cell-based assays for compound screening, target engagement and biomarker development.
  • QC and analyze screening dataset to derive quantitative measurements from cell-based assays. Work closely with biologists and chemists to drive hit finding and SAR for small molecule drug discovery programs.
  • Mentor research associates to develop novel cell-based assays, perform routine screening of compounds, and perform other laboratory experiments as needed.
  • Keep detailed and organized records of experimental protocols and results.
  • Interpret and present scientific findings to at research team meetings. Provide scientific input and propose follow-up studies.
  • Collaborate and communicate across a diverse research team to successfully progress scientific goals. 

Key Qualifications:

  • Ph.D. in a life sciences subject with 2+ years of industry experience in cell-based assay development and small molecule compound screening.
  • Proficiency in cell biology techniques, e.g. mammalian cell culture, live- or fixed imaging, transient transfection, stable cell line generation, cell viability assay, luciferase reporter assays, etc.
  • Familiarity with a variety of cell-based assay readouts including MesoScale, Luminex, CETSA and standard ELISAs.
  • Experience using compound screening databases, preferably with CDD.
  • Demonstrated ability to mentor junior scientists/research associates.
  • Experience with data visualization software programs like Spotfire and Tableau
  • Keen analytical and problem-solving skills.
  • Proficiency in using lab automation to run cell-based assays in 384-well plate format.
  • Ability to communicate clearly and build open collaborative relationships is essential.

Eikon is proud to be an equal opportunity employer and will consider all qualified applicants for employment.