Principal Scientist, RNA Medicines CTI
At Pfizer we strive to deliver Breakthroughs That Change Patients Lives. Our Centers for Therapeutic Innovation (CTI) are an entrepreneurial group within Pfizer that collaborate with leading academic centers and biotech companies to translate the most promising science into novel therapeutics. CTI is seeking a Principal Scientist focused on preclinical research and drug discovery in the field of RNA medicines, based in Manhattan, New York. CTI’s state-of-the-art labs are located within the Alexandria Center for Life Science, NYC, in close proximity to several leading academic centers.
The ideal candidate will be an integral part of therapeutic research project teams that advance CTI’s portfolio. They will work collaboratively with CTI personnel, other Pfizer colleagues and academic or biotech partners to meet aggressive project goals and timelines. The candidate will help drive biology strategy, identify and assess external collaborative opportunities, support assay development, and evaluate molecular mechanisms of action and drug-target pharmacology.
Lead collaborative research with academic and biotech partners to investigate the use of RNA modalities including mRNA, circular RNA, self-amplifying RNA and gene editing, to identify targets and develop therapeutics for rare disease and reprogramming of immune and other cellular lineages.
Seek and evaluate opportunities for partnerships with academic experts, particularly in the fields of rare disease, oncology and immunology & inflammation
Develop assays and research plans that explore the molecular basis for target activity and drug mechanism of action as it relates to disease pathology, including potency, pharmacology and efficacy
Support multiple projects across therapeutic areas, with an emphasis on targets enabled by use of RNA therapeutic approaches
Provide leadership and expertise to team members in the area of RNA medicines
Supervise research associates and/or scientists
Present at group meetings, project team meetings, and site meetings
Proactively seek out new information in the literature and incorporate into individual project(s) as well as the overall program
Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and RNA medicine expertise
Take a proactive role in personal growth and scientific development
Ph.D. in Biology, Immunology, Molecular Biology or related field
Postdoctoral experience and with 5+ years industry experience
Track record of innovative and impactful research including peer-reviewed publications, preferably in rare disease or cellular reprogramming – expertise preferred in liver and/or repeat expansion diseases, RNA pathways, gene editing.
Ability to work in matrixed environment on cross-functional teams
Ability to effectively interact and communicate with multidisciplinary scientists, both internally and externally, excellent communication, interpersonal, and presentation skills essential
Demonstrated ability to identify, evaluate, propose and develop new experimental approaches
Desire to work across different therapeutic areas, applying broad biological knowledge to different targets and teams simultaneously
Experience in RNA medicines preferred
Experience in cell-based assay development beneficial
OTHER JOB DETAILS
Eligible for Relocation Package
Eligible for Employee Referral Bonus
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