Principal Scientist, Disease Strategy (Translational bioinformatics)

Redwood City, California
Jan 21, 2022
Required Education
Position Type
Full time

At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science.In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.


We seek a talented, collaborative inter-disciplinary computational scientist to lead work on the analysis, statistical modeling and generation of hypotheses from high-dimensional tissue, cell and molecular profiling data. This individual will play a key scientific role leveraging innovative computational analysis strategies and rich patient data to empower data-driven decisions in collaboration with BMS Translational Medicine organization.

Analysis scenarios will involve exploratory clinical data and output from transcriptomic, proteomic, genomic, and a wide range of innovative cell-molecular profiling platforms including RNA-seq, specialized genomic panels and transcriptomic assays. Focus for the role will involve translating insights from patient data to model systems including cell lines. Applications range from providing deep insight into tumor progression, subtypes and genetics to deriving therapeutic mechanisms of action for existing and novel therapies as they transition into clinic. Previous experience in solid tumors (including lung, prostate, pancreas) are a plus.

The position would suit an individual with strong scientific leadership potential and excellent communication and collaboration skills. Background in oncology is preferable. Applications are encouraged from those involved in innovative translational biomarker research for oncology indications in clinical or industrial research environments. The role offers the opportunity to impact directly the delivery of truly transformational and life-changing therapies in key diseases of unmet medical need.

Strong interest in the inter-disciplinary application of computational analysis methods to life sciences data is imperative. Areas of particular focus include: elucidation of pleiotropic therapeutic actions via molecular profiling of complex cell culture models; methods to highlight clear mechanistic differentiation between compound mechanisms in key indications; and predictive patient stratification to identify biomarker-defined subgroups of unmet medical need and/or enriched therapeutic response via machine learning analysis of molecular profiling data.


Working in collaboration with computational, biological and clinical scientists across the BMS Research and Early Development organization, responsibilities include but are not limited to:

  • Active participation as a core team member in the IPS Translational Medicine Informatics and Translational Medicine groups.
  • Coordinated application of novel computational analysis and biological interpretation approaches to leverage internal, public and partner datasets and empower data-driven decisions across therapeutic programs.
  • Multi-disciplinary collaboration to investigate compound and disease properties, influence decision making across the translational research and clinical development process, and feedback to inform early development of novel therapies.
  • Data integration across assay platforms and knowledge transfer from pre-clinical experiments to clinical trials.
  • Guide development of molecular patient selection and biomarker hypotheses towards clinical diagnostics.
  • Participation in and oversight of scientific report writing. Presentation of methods, results and conclusions to a publishable standard.
  • Contribution to planning and execution of collaborative projects with leading academic and commercial research groups worldwide.

Background experience & complementary knowledge

  • A Ph.D. in computational biology, bioinformatics, or related field from a recognized higher-education establishment.
  • 5+ years post-doctoral experience of inter-disciplinary computational and molecular biomarker research in university, hospital or biotechnology environments or 5+ years experience in pharma/biotech research environment preferable.
  • Strong knowledge required of predictive analytical practice and molecular diagnostic development. Working knowledge of clinical statistics desirable.
  • Track record of peer-reviewed publication in relevant scientific journals, preferable in applications to oncology.
  • Expertise in algorithmic implementation, statistical programming and data manipulation, using e.g. R/Bioconductor, Matlab, Python, and contemporary, open-source bioinformatics tools and database structures.
  • Proven problem-solving skills, collaborative nature and adaptability across disciplines.
  • Excellent verbal and written communication skills. Fluent verbal and written English language skills prerequisite.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

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