Senior Associate Scientist, In Vivo Pharmacology Oncology (Non-PhD)
At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science.In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
The Tumor Microenvironment Thematic Research Center (TME TRC) focuses on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.
We seek a creative Senior Associate Scientist in the field ofImmune-Oncology/Oncologyto join our In Vivo Pharmacology team within the Tumor Microenvironment Thematic Research Center at Bristol Myers Squibb in Redwood City, California. The successful candidate will play an essential role in the development of advanced models of cancer and the discovery of novel therapeutics for the treatment of cancer leveraging both cancer cell and immune intrinsic biology.
This individual contributor role will collaborate across groups to plan, execute and analyze preclinical mouse studies.A wide range of animal models including syngeneic, GEM, CDX, PDX and humanized tumor models are used. The qualified candidate is a highly motivated, interactive, and team-oriented individual that possesses the ability to work in a multi-functional team environment. You will gain and provide technical and scientific in vivo pharmacology expertise to advance a variety of drug discovery programs from targetidentification/validation,to IND enabling activities and ultimately to clinical Proof of Concept in patients. You will characterize and develop small and large molecule therapeutics in close collaboration with your colleagues within in vivo pharmacology and partner lines (discovery biology, medicinal chemistry, MAP/DMPK, preclinical safety, translational research, and early clinical development) as an integral member of drug discovery teams.
Ideal candidates will havestrong technical skills,a background in characterizing the tumor microenvironment and possess excellent communication skills with a strong commitment to scientific objectivity and excellence.We value both what you do and how you do it.
Conductin vivostudies to evaluate targets, combination strategies, biomarkers and establish efficacy, PK/PD relationships.
Develop novel animal models that more closely mimic human cancer to answer mechanistic questions, discover and validate therapeutic targets, and screen/profile drug candidates.Advancedin vivocancer models include syngeneic, genetically engineered mouse (GEM) and humanized tumor models.
Compliance with IACUC and AALAC regulations.
Interpretation, documentation and presentation of experiments within a multidisciplinary team environment.
Qualifications and Requirements:
Bachelors degree with 5+ years and Masters degree with 2-5 years experience working with animals in academic or industry setting and/or translational drug discovery experience.
Hands on expertise in broadin vivopharmacology skills (dosing, tissue/blood collection, surgery).
Experience with syngeneic and xenograft tumor models is a plus.BS or MS in biology, immunology or a related discipline. Expertise in the tumor microenvironment, oncogenic signaling pathways or immuno-oncology.
Experience with data capturing and analysis software (i.e. electronic notebook, StudyLog, PRISM, Excel).
Excellent interpersonal and communication skills to interact effectively with internal and external colleagues fostering a collaborative workplace environment.
Expertise in in vitro/ex vivo assays including qPCR, MSD/ELISA, scRNAseq, organoids, FACS is a plus.
Travel to local conferences is optional.
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
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