Senior Scientist / Scientist, Process Development (CAR-iT Product & T Cell Differentiation)
- Employer
- Fate Therapeutics
- Location
- San Diego, CA
- Start date
- Jan 20, 2022
View more
- Discipline
- Engineering, Manufacturing & Production, Science/R&D, Biotechnology
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Biotech Beach
Job Details
Responsibilities
- Develop new iT product, support preclinic activities of IND filing, and optimize the iT differentiation process.
- Design, perform and analyze complex multi-stage process parameters to identify critical process parameters in iT production.
- Evaluate or identify new methods or technologies to monitor critical quality attributes of reagents and materials utilized in the differentiation process.
- Act as a subject matter expert from PD to collaborate with internal or external R&D, manufacturing, assay development, regulatory and QC teams for technology or method transfer.
- Train and supervise junior staff members in supporting CMC/IND related activities, including but not limited to protocol driven studies to support process change, premanufacture pilot production, and method qualification.
- Present data to Process Development team, R&D, Tech Ops, and larger program-specific teams.
- Management of reagent inventory and communication to relevant team members.
Qualifications
- Ph.D in cell biology, immunology, bioengineering or closely related field with 4+ years of experience in biotech or pharmaceutical environment
- Track record in process development of cellular therapy is highly desirable
- Extensive hands-on experience with iPSC/ESC differentiation or immune cell culture
- Prior experience in performing laboratory techniques such as, but not limited to, mammalian cell culture, multicolor flow cytometry, cell-based assays such as proliferation and killing assays, cytokine detection, single cell RNAseq, and familiar with in vivo/in vitro cell models relevant to immune cell function
- Prior experience in automations such as ClinicMACS Prodigy, LOVO processing is preferred
- Extensive knowledge in QbD, DOE, statistic data analysis is a plus
- Strong organization skills and ability to multitask
- Strong communication, writing, and presentation skills
- Ability to multi-task and work effectively in a dynamic and fast-paced setting
- Positive outlook, willingness to learn, and a desire to work collaboratively in a team environment
- People management skills a plus
Working Conditions and Physical Requirements
- Will require working with cells and cell lines of human and/or animal origin
- Will require working with hazardous materials
- 100% on-site work at corporate headquarters in San Diego, CA
- Evening and weekend work as necessary
The preceding job description indicates the general nature and level of work performed by employees within this classification. Additional and incidental duties related to the primary duties may be required from time to time.
About Fate Therapeutics, Inc.
Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to the development of first-in-class cellular immunotherapies for patients with cancer. The Company has established a leadership position in the clinical development and manufacture of universal, off-the-shelf cell products using its proprietary induced pluripotent stem cell (iPSC) product platform. The Company’s immuno-oncology pipeline includes off-the-shelf, iPSC-derived natural killer (NK) cell and T-cell product candidates, which are designed to synergize with well-established cancer therapies, including immune checkpoint inhibitors and monoclonal antibodies, and to target tumor-associated antigens using chimeric antigen receptors (CARs). Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit www.fatetherapeutics.com.
Company
Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to bringing a first-in-class pipeline of induced pluripotent stem cell (iPSC)-derived cellular immunotherapies to patients with cancer and autoimmune disorders. Using its proprietary iPSC product platform, the Company has established a leadership position in creating multiplexed-engineered iPSC lines and in the manufacture and clinical development of off-the-shelf, iPSC-derived cell products. The Company’s effector cell pipeline includes multiplexed-engineered, iPSC-derived natural killer (NK) cell and T-cell product candidates, which incorporate novel synthetic controls of cell function, such as chimeric antigen receptors (CARs) to target tumor-associated antigens and are intended to deliver multiple mechanisms of therapeutic importance to patients including in combination with well-established cancer therapies. Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit www.fatetherapeutics.com.
- Website
- http://www.fatetherapeutics.com/
- Phone
- 858.875.1800
- Location
-
12278 Scripps Summit Drive
San Diego
California
92131
United States
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