Scientific Lead, Translational Human Geneticist – Cardiometabolic disease

Location
Tarrytown, New York
Posted
Jan 18, 2022
Ref
REGEA0026R3442
Discipline
Science/R&D, Pathology
Required Education
Doctorate/PHD/MD
Position Type
Full time

We are looking for a talented Human Genetics Scientist to join the cardiovascular, Metabolic and Musculoskeletal Therapeutic Area Genetics team at the Regeneron genetics center (RGC). The mission of the team is to discover new disease biology, highlight new drug targets, select indications for drug programs, and identify subgroups of patients who are more likely to respond to treatment through genetic analyses of over 1 million sequenced individuals. The Regeneron Genetics Center houses one of the world’s largest and most complete datasets on human genetics in the world. This is a fantastic opportunity to join an inspiring and talented team that is on the forefront of genetics based drug discovery and translational genetics.

You will take on responsibilities for the design, execution, and interpretation of genetic association studies and epidemiological studies of cardiometabolic traits. In this role, you will translate genetic findings into actionable insights, for example: identifying patient populuations, identifying or validating drug targets and testing hypotheses that can lead to new insights in human biology of cardiometabolic diseases. To do this, you will work together with the inclusive and multidisciplinary teams and colleagues at the RGC and Regeneron to translate genetic findings into actionable insights. In this role, you will closely interact with pre-clinical teams to develop and test hypotheses in our large scale genetic datasets and generate new hypotheses for functional modelling.

In this role, a typical day might include the following:

  • Design, initiate or perform genetic epidemiology studies of cardiovascular, metabolic and musculoskeletal traits.
  • Hypothesize on the biological mechanisms and clinical implications of genetic associations. 
  • Closely interact with pre-clinical and clinical teams at Regeneron to generate new hypotheses for functional modeling and contribute to the design of clinical studies.
  • Closely interact with the analytical genomics team to perform and interpret large scale analyses of the 1M+ sequencing data to generate new biological hypotheses around cardiometabolic disease. 
  • Survey the literature and scientific conferences to incorporate discoveries and findings from the broader genetics community into study opportunities and considerations internally.
  • Generate, summarize and present results in internal and external meetings to a variety of audiences. 
  • Trial blue sky ideas.
  • Lead and contribute to the writing of scientific reports and publications.
  • Represent the Therapeutic Area Genetics team in cross-functional initiatives within RGC, Regeneron and international research community.
  • Collaborate with external industry and academic partners in scientific consortia.
  • Deliver reliable analyses across projects in a high-pace working environment.

This job might be for you if you have:

  • A strong work ethic and are proactive in providing solutions, foster scientific collaborations and drive projects forward.
  • A drive to understand the genetic basis and causes of cardiometabolic diseases and translating this knowledge into biological insights. 
  • Previous experience with individual level data of population based cohorts studies is a plus. 
  • An understanding of basic biology and familiarity with basic science in a wet-lab environment. 
  • Experience with programming or scripting languages to perform statistical analyses. 
  • Outstanding personal initiative and the ability to work effectively as part of a diverse team of colleagues. 
  • The ability to summarize and present the results of human genetic studies to a variety of audiences.
  • A commitment to high-quality science and to the highest standards of research and work ethics and integrity.

To be considered for this role, you must have a PhD in Statistical Genetics, Genetic Epidemiology, Human Genetics, Computational Biology or related field with good computational skills. Individuals with a background in molecular biology, biotechnology, biochemistry or similar with good computational skills and experience with human genetics are also encouraged to apply. Proficiency in navigating Unix/Linux systems. Demonstrated ability in a scripting or programming language – proficiency in R, preferred.

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Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!


Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.