Scientist, Translational Science & Biomarkers

Location
Redwood City, CA
Posted
Jan 18, 2022
Hotbed
Biotech Bay
Required Education
Doctorate/PHD/MD
Position Type
Full time

Scientist, Translational Science & Biomarkers
The Position:
We have an exciting opportunity for a highly collaborative Scientist to join our Biomarker, Translational Science team. Strong candidates will be self-motivated and embrace the chance to wear many hats in adynamic startup environment. You will contribute to pre- clinical and clinical programs by developing and validating biomarkers for clinical trials.
Job title will be commensurate with experience. This newly created position will be a key contributor to developing clinical biomarkers through preclinical mechanism of action studies.

Key Responsibilities:
This position is expected to work independently to design, conduct and analyze experiments and will be involved in defining the immunologic activity and mechanisms of action of cancer immune-therapeutics and will collaborate extensively with Bolt staff. In this role, you will keep excellent records of protocols, methods and experimental data and communicate key results in meetings and to collaborating staff. This position will require ~50% of time to perform laboratory research.

Responsibilities include, but not limited to:
Developing novel in vivo and ex vivo methods to evaluate mechanism of action (MoA) oftherapeutics being developed by Bolt
Using pre-clinical models to identify clinical biomarkers supporting MoA of the therapeutics
Performing biochemical, molecular, cell based, in-vivo, ex-vivo and/or immunological assays tosupport clinical and pre-clinical projects using mouse and human samples
Analysis and presentation of biomarker data from pre-clinical experiments
Contributing to scientific ideas and evaluating key hypotheses that advance company technologiesand clinical development.

Job Requirements:
Ph.D. in immunology, cell biology, or cancer biology; with minimum 2 years of relevant industryexperience
Prior experience working in cancer immunotherapy field
Experience working with and knowledge of various xenograft and syngeneic mouse cancer models
Experience with multi-color flow cytometry and processing of mouse tissues for profiling tumor-infiltrating immune cells
Expertise in immune cell activity assays including ADCP, MLRs and ELISPOT, purification ofPBMCs, and derivation of macrophages and dendritic cells
Basic molecular and cellular techniques such as immunoassays (ELISAs), cell culture, RNAisolation, processing and analysis
Expertise analyzing genomic expression datasets (R, Python, etc.) would be a plus
Experience with IHC a plus.
Ability to manage activities related to assigned projects with minimal supervision
Ability to analyze and interpret scientific data independently
Ability to work effectively and collaboratively in a fast-paced, dynamic environment
Excellent communication, technical writing, organizational and collaboration skills


Who We Are:
Bolt Biotherapeutics, based in the San Francisco Bay Area, is a clinical-stage biotechnology company developing Boltbodyâ„¢ Immune-stimulating Antibody Conjugates (ISACs), a new class of immuno-oncology therapeutics that have eliminated tumors following systemic administrationin preclinical studies while also developing immunological memory, which may lead to more durable clinical responses for patients. This is a unique opportunity to join and build, with like- minded colleagues, a company that will transform the lives of individuals with cancers. We are an Equal Opportunity Employer offering a competitive salary and benefits package.