Senior Research Scientist, Medicinal Chemistry

About IDEAYA Biosciences:
IDEAYA Biosciences (NASDAQ: IDYA) is a public, clinical-stage synthetic lethality-focused precision medicine oncology company committed to the discovery and development of targeted therapeutics for patient populations selected using DNA sequencing and other molecular diagnostics. Our approach integrates extensive capabilities in identifying and validating translational biomarkers with small molecule drug discovery to select patient populations most likely to benefit from the therapies we are developing. We are applying these capabilities across multiple classes of precision medicine, including direct targeting of oncogenic pathways and synthetic lethality – which represents an emerging class of precision medicine targets. We believe this diversified approach will enable us to deliver the right medicine to the right patient to drive a more robust clinical response.
IDEAYA recently announced a landmark strategic partnership with GSK in Synthetic Lethality for certain pipeline programs. The GSK partnership is transformative and enables IDEAYA and GSK to collectively build an industry leading platform and pipeline in Synthetic Lethality. For more information, please see www.ideayabio.com.

Position Summary:
We are seeking a talented and highly motivated individual with significant synthetic chemistry experience to join our multidisciplinary team. The successful candidate will engage in rational structure-based drug discovery enabled by our computational and structural chemistry group. In addition to significant lab work, the work will include aspects of managing CRO collaborators in the preparation of target molecules. As a member of a dynamic multi-disciplinary team, this person will collaborate with a broad group of scientists within IDEAYA as well as external collaborators.

Requirements:

• Ph.D. in synthetic organic chemistry with 0 - 3 years of pharmaceutical industry medicinal chemistry experience or master’s degree with 3 - 8 years of experience
• Excellent scientific expertise in organic chemistry, strong knowledge of modern chemistry literature and in-depth knowledge of a wide range of purification and spectroscopic characterization techniques. Ability to regularly troubleshoot synthetic problems and provide practical and creative solutions.
• Maintain a high level of productivity in the lab
• Excellent oral and written communication skills
• Ability to multi-task and set priorities, possibly on multiple projects
• Ability to work well in multi-disciplinary teams

Preferred Requirements:

• Track record in applying modern synthetic organic techniques to advance small-molecule drug discovery programs.
• Understanding of medicinal chemistry concepts and proficiency in the application of structure-based design with demonstrated success in application to medicinal chemistry design challenges.
• Knowledge of ADME, physicochemical, biochemical and pharmacological principles as applied to drug discovery
• Solid ability to supervise CRO collaborators to high levels of productivity

The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law). Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law. The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.

Benefits
When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use team work to move science forward.

Ideaya is an equal opportunity employer. In accordance with applicable law, Ideaya does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets.