Senior Research Associate, Research (Solid Tumors)

South San Francisco, California
Jan 11, 2022
Biotech Bay
Required Education
Masters Degree/MBA
Position Type
Full time
Thank you for your interest in a career at Senti Biosciences. Our mission is to create a new generation of smarter medicines that outmaneuver complex diseases in ways previously inconceivable. We are passionate about designing gene circuits to improve the “intelligence” of cell and gene therapies in order to enhance their therapeutic effectiveness against a broad range of diseases that conventional medicines are unable to address.
At Senti, we find purpose and meaning knowing that our efforts have the potential to improve the lives of patients and their families with more effective and safer treatment options. With science as our foundation and empathy as our key guiding principle, colleagues become friends, managers become mentors, and with time, cancer becomes history.

Our team is seeking a talented, passionate and driven Research Associate to join our team developing logic gated immune cells for the treatment of solid tumors.
The successful candidate must be knowledgeable and have prior experience in performing immune phenotyping and cell-based functional assays independently and work collaboratively across various project teams to meet deadlines and milestones.
Most of all, we are seeking a curious, bold, detail-orientated, and collaborative individual, who is eager to be part of a positive work environment with other researchers to develop much needed novel cell therapies targeting cancer.
  • Perform immunology phenotypic and functional assays such as using multi-color flow cytometry, protein quantification, Luminex, ELISA, gene-expression, etc.
  • Experience in functional assays: co-culture, cell killing assays, etc.
  • Experience in performing in vivo experiments and downstream assays (flow cytometry, gene-expression).
  • Write and follow SOP, maintain detailed electronic lab records, perform data analysis and generate conclusions and new hypothesis. 
  • Excellent communication skills and ability to present experiments to the team.
  • Collaborate with your Senti colleagues by coordinating with other group members and research teams to troubleshoot problems, develop new assays and protocols, and support cross-functional projects

  • BS or MS or equivalent expertise in Cell Biology, immunology, Tumor Immunology, or similar.
  • 4-5 years of research experience in a biology laboratory setting; industry experience is a plus.
  • Hands-on experience with chimeric antigen receptors (CARs) and other cell therapies modalities.
  • Experience with pre-clinical models of solid tumors and downstream tissue processing and analysis (flow cytometry of murine samples and IHC).
  • Excellent understanding of immune cell biology, preferentially NK cell biology
  • Hands-on proficiency with immune primary cells culture and phenotypic and functional assays, including cell-based assays measuring cell proliferation, cytotoxicity, and cytokine production.
  • Experience with multicolor flow cytometry and data analysis.
  • Ability to quickly adapt to new research areas and implement new techniques with minimal supervision.
  • Demonstrated ability to work independently and as part of a multi-functional team.

Salary and Benefits
  • Competitive compensation package and title commensurate with qualifications and experience in the South San Francisco Biotech market.
  • Significant growth opportunity as the company expands
  • Empathetic, supportive and collaborative colleagues and work environment

Senti Bio is a leading gene circuit company designing gene circuits to create a new generation of “smarter medicines" and enhance the therapeutic effectiveness of cell and gene therapies against a broad range of diseases that are unaddressed by current standards of care. We are proud to count Leaps by Bayer, NEA, 8VC, Matrix Partners China, Mirae Asset Capital, Amgen Ventures, and others among our investors. In December 2021, Senti Bio and Dynamics Special Purpose Corp. (Nasdaq: DYNS), a special purpose acquisition company (SPAC), announced a definitive business combination agreement to create a public company focused on Gene Circuit-engineered cell and gene therapies. The transaction is expected to be completed in the second quarter of 2022. Senti Bio is based in South San Francisco, CA, USA.

We are committed to an inclusive and diverse Senti Bio. We believe that different perspectives lead to better ideas, and better ideas allow us to better understand the needs and interests of our diverse Senti Team. We welcome people of different backgrounds, experiences, abilities and perspectives and are an equal opportunity employer.