Flatiron Research Fellow, Structural and Molecular Biophysics

New York, NY
Jan 11, 2022
Required Education
Position Type
Full time

Tremendous opportunities for discovery are emerging in the biological and biomedical sciences, as well as in traditional physical and social sciences, but they will require the combined power of theory, data analysis, and simulation. In the biomedical sciences, for example, researchers are being confronted by an explosion of information from genome sequencing, gene expression profiling, proteomics, multi-electrode recording, and multiple high-resolution imaging modalities. The mission of the Center for Computational Biology is to create new computational frameworks that will enable scientists to analyze the large and complex data sets that are being generated by these new experimental technologies. Principle areas of research include biophysical modeling, development dynamics, genomics, molecular biophysics, and systems biology.

The Flatiron Institute is dedicated to advancing scientific research through computational methods, including data analysis, theory, modeling and simulation. It currently houses five science centers, focused on computational astrophysics (CCA), computational biology (CCB), computational mathematics (CCM), computational neuroscience (CCN) and computational quantum physics (CCQ), as well as a scientific computing core.

CCB and CCM have created a joint research group in Structural and Molecular Biophysics. The goals of this new group include the creation of new computational methods that will enable scientists to analyze the large, complex data sets that are being generated by new experimental technologies, as well as new simulation techniques for molecular and structural modeling.


Applications are invited for a post-doctoral Flatiron Research Fellow (FRF) position with Structural and Molecular Biophysics at the Center for Computational Biology (CCB).

In addition to conducting independent research, Flatiron Research Fellows in Structural and Molecular Biophysics will apply and develop methods in molecular dynamics (MD) simulation to better understand mechanisms of biological importance, such as ion channel function. In addition, they will work closely with experimental data and experimentalists to better combine single molecule and/or cryo-EM data with MD to improve our understanding of protein dynamics.

More generally, Flatiron Research Fellows will disseminate their results through scientific publication or software release, collaborate with other members of the Center for Computational Biology and/or other Flatiron Institute research centers, and participate in the life of the Center for Computational Biology, and Mathematics, the Flatiron Institute by attending seminars, colloquia, group meetings and other opportunities for scientific exchange.

FRF positions are generally two-year appointments and can be renewed for a third year, contingent on performance. FRFs receive a research budget and have access to the Flatiron Institute's powerful scientific computing resources. FRFs may be eligible for subsidized housing within walking distance of the Flatiron Institute.

These positions will be based in our New York City offices.



  • Applicants are required to have a Ph.D. in biochemistry, biophysics, physics, applied mathematics, computational biology, computer science, or related disciplines or, if selected, will receive their PhD before the start of the FRF appointment.

Related skills and other requirements

  • Exceptional abilities in molecular simulation and analysis, statistical mechanics, and/or relevant methods in computational biology.
  • Ability to do original and outstanding research in computational biology
  • Ability to work well in an interdisciplinary environment, and to collaborate with experimentalists
  • Strong oral and written communication, data documentation, and presentation skills
  • Excellent collaborative and interpersonal skills required.


  • Cover letter (optional)
  • Curriculum vitae with bibliography
  • Research statement of no more than three (3) pages describing the applicant's past work and potential synergies with activities at Structural and Molecular Biophysics and the Flatiron Institute as a whole.
  • Two (2) letters of recommendation submitted confidentially by the recommenders directly to ccbjobs@flatironinstitute.org.

Please submit all application materials by December 3, 2021. Interviews with selected candidates will take place during the last two weeks of January 2022.


Many of the greatest ideas and discoveries come from a diverse mix of minds, backgrounds and experiences, and we are committed to cultivating an inclusive work environment. The Simons Foundation actively seeks a diverse applicant pool and encourages candidates of all backgrounds to apply. We provide equal opportunities to all employees and applicants for employment without regard to race, religion, color, age, sex, national origin, sexual orientation, gender identity, genetic disposition, neurodiversity, disability, veteran status, or any other protected category under federal, state and local law.