Research Associate/Senior Research Associate

Research Associate/Senior Research Associate - DMPK

Arcus Biosciences is seeking a highly motivated and team-oriented individual for the position of Research Associate in the Drug Metabolism and Pharmacokinetics (DMPK) Department. The successful candidate will be responsible for conducting routine in-vitro ADME studies, qualitative and quantitative analysis of small molecules using LC-MS/MS, to support multiple drug discovery and development projects.

Responsibilities include, but are not limited to:

• Perform LC-MS/MS method development and quantitative analysis of small molecules in various biological matrices.
• Conduct routine in vitro studies including, but not limited to, metabolic stability, CYP P450 inhibition and Time Dependent Inhibition assays.
• Perform other in vitro ADME studies such as plasma protein binding, blood-to-plasma partitioning, and CYP phenotyping as needed.
• Perform data analysis and reporting of experimental results to project teams.
• Maintain and troubleshoot LCMS instruments.

Qualifications:

• BS/MS degree in biochemistry, pharmaceutical science, or related scientific discipline with 1-4 years of relevant experience
• Hands-on experience in LC/MS/MS method development and quantitative analysis of small molecule using LC/MS/MS instruments, preferably SCIEX 4000, 5500 or 6500 series
• Experience with in vitro ADME assays is highly desirable.
• Experience with liquid handling systems, Tecan and Bravo, is a plus.
• Detail-oriented, strong work ethic, self-motivated, and proven ability to work both independently and collaboratively in a team environment
• Excellent communication and writing skills