Senior Scientist, Translational Modeling and Simulation

Cambridge, MA
Jan 01, 2022
Required Education
Position Type
Full time

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.  



The successful applicant will join the Translational Modeling and Simulation team within Pfizer’s Medicine Design organization which applies state-of-the-art modeling and simulation methodologies to preclinical programs to enable key drug discovery decisions from early discovery stages through early -clinical studies. As a member of Cambridge (US)-based multidisciplinary project teams, the candidate will develop and implement quantitative, mechanism-based mathematical models which impact decisions regarding molecular target and interventional modality evaluation, biomarker characterization, chemical optimization and candidate selection, preclinical-clinical translation strategies and early clinical trial design.


The successful applicant will have an opportunity to support a range of projects within Pfizer’s small molecule portfolio. Implementing translational science, to predict human dose and therapeutic index, will be an important task supporting projects transitioning into the clinic. In the earlier phases of drug discovery, the deployment of mechanistic modeling and/or systems pharmacology modeling is an essential responsibility for guiding discovery teams to evaluate the therapeutic potential of novel molecular targets, define laboratory objectives, design and interpret in vitro and in vivo pharmacology studies and select appropriate compounds for clinical development. To this end, the successful applicant will partner with biologists and other experimentalists in implementing emerging methodologies and technologies relevant to drug discovery. The successful applicant will have the opportunity to work with multiple stakeholders outside of the modeling and simulation discipline (e.g. Medicinal Chemistry, Biology, DMPK, Drug Safety, Pharmaceutical Sciences, Clinical Pharmacology, Clinical). The individual is expected to keep up to date with emerging literature and science in modeling and simulation sciences and will have the opportunity to present scientific results both internally and externally through conference presentations and publications. Given the global nature of project teams and group members, excellent communication skills, a pro-active approach and independence are preferred characteristics for the successful applicant.



  • Ph.D. degree or equivalent degree in systems biology, pharmacometrics, pharmaceutical sciences, engineering, physics, mathematics, or similar disciplines where modeling and simulation is emphasized.

  • 0 – 2 years of relevant experience in the pharmaceutical industry

  • Familiarity, through experience, with the phases of drug discovery and development, with particular emphasis on compound selection and translational research issues (preferred, but not required).

  • Strong communication skills, ability to work independently and in teams, and attention to detail.


  • Excellent understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulation

  • Hands-on knowledge of the state-of-the-art modeling and simulation software and applications in the area of PKPD modeling and simulation (e.g. NONMEM, MatLab, Phoenix, Berkeley-Madonna, SAAM II, ADAPT, ACSL, S-plus, R or comparable applications).

  • An understanding of the basic principles of pharmacokinetics (e.g. non-compartmental, compartmental, PBPK)

  • Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop mechanistically-relevant PK-PD models

  • Ability to translate/condense/summarize outcomes ofmodeling and simulation analyses into information that can be used by project teams

  • Ability to keep up-to-date with and propose the implementation of scientific and technological developments in the area of PK-PD modeling and simulation

  • Good team player and communicator; including good listening skills and the ability to effectively interact with colleagues with a variety of backgrounds

  • Ability to work in a small team with minimal technical supervision (self starter) and remote team members

  • Motivated to develop a career as a hands-on, technical modeling and simulation expert in a preclinical drug discovery environment

  • Keen to interact as a modeling and simulation expert with matrix project teams working closely with PDM, Biology and Clinical scientists

  • Strong belief that modeling and simulation can have a significant positive impact on research projects

  • Committed to the development of self and others

  • Motivated to share technical expertise with others


Occasional travel, 1 - 2 times a year, may be needed.


  • Relocation support available

  • Eligible for employee referral bonus

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment.  As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.  These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.

Research and Development