Senior Scientist I.II, Conjugation Chemist

About AbbVie
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

AbbVie has an opening for a Senior Scientist I.II in Discovery to conduct pre-clinical research and development in the area of antibody drug conjugates (ADCs).

Key Responsibilities Include

• Synthesis, purification and characterization of ADCs on mg to gram scale.
• Development and optimization of conjugation protocols utilizing novel chemistries and technologies.
• Development and optimization of automated techniques for ADC synthesis and purification.
• Collaboration with Therapeutic Area Project Teams, as well as core Chemistry, Protein Science and Process Development teams to expand conjugation capabilities at Abbvie.

Qualifications

• Ph.D. in Organic Chemistry/ Biochemistry/Chemical Biology or other relevant discipline with typically 0-3+ years of relevant experience.
• Hands-on experience with generation and characterization of antibody drug conjugates preferably in the area of biotherapeutics.
• Proficient in analytical techniques including Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid chromatography–mass spectrometry (LC-MS), Ion-Exchange (IEX), Reversed Phase (RP)-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF).
• Hands-on experience and knowledge in protein purification using HIC, IEX, SEC and affinity chromatography.  Experience with GE AKTA FPLC and unicorn software preferred.
• This position requires an individual who is self-motivated, enthusiastic, hard-working, detail-oriented and able to work in a fast-paced team environment with demonstrated problem solving skills.
• High-quality written and oral communication skills and the ability to excel in a collaborative environment are essential.

Key Leadership Competencies

• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
• Learns fast, grasps the "essence" and can change course quickly where indicated.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Significant Work Activities
N/A
Travel
No
Job Type
Experienced
Schedule
Full-time
Job Level Code
IC
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.