Principal Scientist, Medicinal Chemistry

Cambridge, MA
Dec 27, 2021
Required Education
Position Type
Full time

General Scope and Summary

SAGE Therapeutics is searching for a creative, resourceful, integrative thinker for an important role as the Principal Scientist, Medicinal Chemistry. The candidate will have a strong track record in drug discovery to lead our Medicinal Chemistry program focusing on small molecule drugs for CNS disorders.  A demonstrated ability to thrive in a dynamic, fast-paced, start-up environment will be essential as well as strong managerial and organization skills in an outsource setting.  The position requires individuals with an exceptional grasp of the entire interdisciplinary drug discovery process from lead generation to development candidate nomination.  In addition, the candidate will have demonstrated highly tuned people management, organizational and decision making skills.  Excellent written and oral communication skills are required, as is the desire and ability to excel in a multidisciplinary environment as an integral leader and member across multiple project teams.

Roles and Responsibilities

  • Design, implement and execute medicinal chemistry tactical strategies at various CRO’s. 

  • Establish partnering strategies to leverage external knowledge and capabilities, and effectively plan resource allocation to achieve team goals

  • Provide strategic, scientific and managerial leadership in an outsourced Medicinal Chemistry environment

  • The ability to interact and contribute to internal multidisciplinary drug discovery project teams is essential

  • Provide timely and well organized reports to project teams

  • Collaborate effectively with the leadership team and other departmental managers and functions.

Experience, Education and Specialized Knowledge and Skills

Must thrive working in a fast-paced, innovative environment while remaining flexible, proactive, resourceful and efficient. Excellent interpersonal skills, ability to develop important relationships with key stakeholders, good conflict management and negotiation skills, ability to analyze complex issues to develop relevant and realistic plans, programs and recommendations. Demonstrated ability to translate strategy into action; excellent analytical skills and an ability to communicate complex issues in a simple way and to orchestrate plans to resolve issues and mitigate risks.

Basic Qualifications

  • Doctoral degree (PhD) or equivalent in synthetic organic chemistry or medicinal chemistry

  • 7+ years of experience in the pharmaceutical industry, with a strong track record of scientific innovation and success in delivering clinical candidates

  • In-depth knowledge of the entire drug R&D processes, expertise in ADME/PK, pharmacology and computational chemistry is essential

Preferred Qualifications

  • A natural leader with effective organizational, interpersonal, communication and managerial skills who is able to motivate and inspire others

  • Demonstrated leadership of project teams in a cross-functional environment

  • Demonstrated technical proficiency, scientific creativity, independent thought, and ability to effectively collaborate with others

  • Embrace our core values: Put People First, Do Big, Be Accountable, Grow through Learning and Change, and Work Fun

  • Excitement about the vision and mission of Sage

Employment Type:Employee

Number of Openings:1

Job ID:R000740

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All Sage new hires will be required to provide documentation that they are fully vaccinated against COVID-19 or, if not, that they are legally entitled to an accommodation due to a medical condition or a sincerely held religious belief.  Requests for accommodation will be considered on a case-by-case basis, and Sage will consider, among other things, whether the proposed accommodation would create an undue hardship.

All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

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We value our relationships with professional recruitment firms. To protect the interests of all parties, and given the large volume of inquiries received from third-party placement agencies, we are not able to respond to all agency inquiries. We do not accept unsolicited resumes from any source other than directly from candidates for current or future positions. Submission of unsolicited resumes in advance of a signed agreement between our company and a placement agency does not create an implied obligation and, if an unsolicited candidate represented by a placement agency is hired, we are not obligated to pay a fee. Only approved recruitment firms will be allowed to provide services to Sage Therapeutics, Inc.