Sr. Associate Scientist, Inflammation

Sr. Associate Scientist, Inflammation
United States - California - Foster City

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

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Description:

We are seeking a highly motivated Associate Scientist to join our inflammation group. The candidate will be responsible for evaluating novel inflammatory therapeutics in pre-clinical models of rheumatoid arthritis, lupus, autoimmune encephalomyelitis, and colitis. Hands on experience and substantiated knowledge with preclinical models of inflammatory autoimmune diseases is required. The successful candidate will be responsible for designing, generating and communicating pharmacology data of preclinical models internally to support inflammatory target discovery for autoimmunity. Title will be commensurate with industrial experience and previous track record of research article/patent publication.

Primary responsibilities:

Designing, conducting, analyzing and reporting in vivo studies (efficacy, PK/PD)

Pre-clinical model development, optimization, and characterization

Interface with cross-functional project team members, and participation in and presentation at project team meetings and cross-departmental team meetings

Qualifications & prior experience:

MS in Biology or Pharmacology related discipline

8+ years of research experience in an industry setting and good understanding of inflammatory disease pathogenesis

Research experience with hand-on experience in mouse models of inflammatory animal models including but not limited to collagen induced collagen induced arthritis, autoimmune encephalomyelitis, OVA induced asthma, and/or experimental colitis

Proficiency with various mouse handling techniques including dosing (IV, PO, subcutaneous, IP), preclinical manifestation scoring (e.g., joint swelling, paralysis), and collection and handling of tissues during necropsy and processing for ex vivo analysis

Experience with lymphocyte FACS sorting, magnetic bead-based cell isolation, and flow cytometric analysis are highly preferred

Excellent organizational and communication skills, along with the ability to work effectively in a multidisciplinary team environment

The ability to work independently on day-to-day responsibilities and research goals

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