Informatics Scientist, Lead Discovery

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Position

Nurix is seeking a highly skilled and motivated Informatics Scientist to contribute to a variety of data engineering, database design/maintenance, and data analysis environment augmentation workflows. You will interface with fellow scientists across the organization to understand the informatics needs and design, build, and deploy impactful solutions.  In this role, you will help fellow scientists effectively manage, use, and integrate Nurix’s existing databases and applications to capture, analyze, query and report chemical and biological data to support our DNA-encoded library platform.  You will partner with your Informatics colleagues to implement database-backed solutions to address unmet automation and informatics needs.

Required Qualifications:

• Minimum 2 years’ experience working with databases (Oracle, MySQL, PostGRES, etc), including database design and SQL coding
• Fluent in Python and demonstrated track record of algorithm design and implementation
• Excellent communication and presentation skills on the phone, in 1x1 meetings, and in a group setting
• Strong written communication skills to create business-appropriate emails, instant messages, requirements/specifications documents, presentation materials, etc.
• Proficient in MS Office (Excel, Word, PowerPoint)

Preferred Qualifications:

• Experience of supporting databases in biotech/pharmaceutical industry
• Experience with data analysis and visualization tools, especially Python Pandas and TIBCO Spotfire
• Experience with data transformation (ETL), data preparation processes and tools
• Demonstrated experience in database architecture design with consideration of platform, performance, security, scalability, and supportability
• Demonstrated experience in supporting and optimizing large database applications including performance analysis and tuning of high volume
• Hands on experience and extensive knowledge of AWS technologies specially in the areas of database, server, storage, and security, preferable with AWS EC2, RDS and native databases
• Experience in setting up controlled vocabularies, creating a user-friendly experience uploading and interacting with data.
• Proficient with both Linux and Windows operating systems
• Ability to work well independently to successfully complete a task from beginning to the end with minimal supervision
• Attention to detail and the ability to work individually, within a multi-disciplinary team, as well as with external partners and vendors.

Fit with Nurix Culture and Values

• Strong team orientation, highly collaborative
• Solutions and results-oriented focus
• Hands-on approach, resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.