Scientist / Sr. Scientist – CMC Analytical Characterization

ABOUT GREENLIGHT

GreenLight Biosciences solves big problems facing society in agriculture, human health, and animal health through scientific innovation. GreenLight Biosciences is dedicated to bringing our cell-free RNA production process to market. Our work will lead to more sustainable global development, and we promise to deliver our safe solution without compromising the Earth and its people. One of the small coterie of early RNA-focused biotech startups, GreenLight Biosciences was founded in 2008, raised its most recent round this year and has a broad portfolio addressing key issues in plant health and human health. The GreenLight team is over 200 people across our headquarters in Medford, MA, an R&D facility in Woburn, MA and an R&D facility in Research Triangle Park, NC. GreenLight also has a pilot scale biomanufacturing plant in Rochester, NY. Initiatives include finding ways to support biodiversity, protect bees and other pollinators, treat rare diseases such as Sickle Cell Disease as well as develop vaccines for seasonal flu and the current COVID-19 pandemic. 

At GreenLight, we believe inclusion is the way forward. We celebrate the power of working together to address humanity’s challenges, meet the needs of underserved populations, and push the boundaries of scientific discovery. Fueled by our aspiration for a true sense of belonging, our talented teams embody the principles of diversity and equality as we strive to bring food security, medicine, and healthcare to everyone—paving the way for a sustainable future. For more information, visit www.greenlightbio.com. 

We are seeking an analytical scientist responsible for the development of analytical methods and characterization of materials for the creation of fundamental product and process understanding and the advancement of innovative approaches to drug development. The incumbent will be highly motivated to work in a science driven and collaborative environment to achieve GreenLight’s program milestones. The successful candidate will have experience with bioseparation methods (HPLC, CE, etc.) and/or mass spectrometry and should be able to work with minimal supervision to carry out laboratory based de novo analytical method development and characterization activities for GreenLight’s RNA vaccines and therapeutics.

MAJOR RESPONSIBILITIES

• Drive structure/function studies and other characterization activities to advance product and process understanding
• Perform in-depth analytical characterization of RNA drug substance and RNA-LNP formulations, including reference standards and materials for comparability studies
• Identify and characterize low-level variants and impurities originating from the product, manufacturing process, or raw materials
• Develop and implement fit-for-purpose characterization methods
• Contribute to quality attribute criticality assessments and establishment of analytical control strategy
• Interface with discovery groups to ensure a smooth transition of analytical methods and product understanding to CMC development
• Author or review technical documents to support regulatory submissions, including IND/CTA and registration applications
• Report and discuss analytical results and conclusions both orally and in writing

EDUCATION

• PhD in analytical chemistry, chemistry, biochemistry, chemical engineering, molecular biology or related field with 0-8+ years of industry or post-doctoral experience. Qualified candidates with a BS/MS degree will also be considered.

PROFESSIONAL EXPERIENCE / QUALIFICATIONS

• Demonstrated ability to perform in-depth characterization of novel biologics and critical quality attribute (CQA) assessment
• Experience in structure/function relationship studies and late-phase CMC activities
• Experience in analytical method development for nucleic acids and lipids is strongly desired
• Prior experience working with analytical methods for RNA-based vaccines or therapeutics is preferred, but is not required
• Strong expertise in bioseparation techniques (HPLC, CE) and/or in mass spectrometry (LC-MS) analysis is required
• Familiarity with biophysical characterization such as UV, FTIR, CD, fluorescence spectroscopy, DLS, SEC/FFF-MALS, SV-AUC, NTA, DSC, ITC, particulate analysis (MFI, HIAC), is a plus
• Familiarity with molecular biology techniques, qPCR, NGS, in vitro transcription and translation is a plus
• Strong capabilities in experimental design and execution
• Ability to self-start and work autonomously in a fast-paced environment
• Demonstrated critical thinking, problem solving, and innovation capabilities
• Effective collaboration, communication, and negotiation skills
• Experience in leading small teams and supervising junior scientists is a plus

Greenlight Biosciences Inc. provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

GreenLight requires proof of COVID-19 vaccination for its employees consistent with OSHA guidelines.