VP, R&D, Promoter & Gene Regulation

4DMT is focused on attracting and retaining the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers competitive salary and benefits, and provides challenging opportunities for career development.  4D Molecular Therapeutics is located in Emeryville, CA.

GENERAL SUMMARY:
Reporting to the CSO, this is a senior strategic role in the Technology & Innovation Group (TIG).

TIG functions to develop new innovative technologies for direct application in our product pipeline of transformative AAV-based gene therapies. We seek a seasoned biopharmaceutical leader with experience in promoter, genetic regulation and/or transgene engineering to head up a group of scientists developing novel innovative promoter, gene regulation, and transgene solutions for the 4DMT product portfolio. The VP will have responsibility for the strategy, process and execution of the science whether this be in-licensing of new technology or in-house development. The VP will have a key role in scientific leadership and research governance within the company and will work closely with other functions including Corporate Strategy, Business Development, and CMC and will interface regularly with the Executive Team, Clinical Operations, Regulatory, CMC. The role needs a motivated, driven, and experienced highly-scientist that can work within a driven cross-functional team in a fast-paced work environment. 
Responsibilities

• Develop the strategy for technology develop in the relevant field
• Work closely with the Therapeutic Area Heads, Project Leaders and the Chief Scientific Officer to develop innovative approaches to promoters and gene regulation and apply to AAV gene therapies
• Contribute to the strategy, assessment and prioritization of the 4DMT product pipeline and Therapeutic Areas
• Lead a team of scientists in develoing the strategy, design and implementation of research programs in both promoter discovery and optimization as well the development of gene regulation technologies including genetic switches
• Contribute substantially to the evaluation of external technologies, potential in-licensing and out-licensing opportunities working closely with Corporate Strategy
• Work closely with the project management office to manage budgets and timelines
• Contribute to the strategy and preparation of regulatory submissions such preIND, INTERACT, IND, Orphan Drug Designation, Fast Track & EMA submission
• Present and interact Executive Team and governance groups (e.g. R&D Leadership, Strategic Portfolio Review and Project Review Committees to meet strategic objectives and company goals, identify program risks and develop risk mitigation plans.
• Build and manage preclinical scientific advisory boards/meetings and external consultants.
• Develop strategy for publications in this field and present at external scientific presentations and publications
• Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time

Qualifications

• PhD in relevant field (e.g., gene regulation, genetics, molecular biology, pharmacology,
Experience:

• 10+ years industry/pharma experience or equivalent in academia and faculty level (associate professor or above)
• Strong track record of independent scientific achievement
• Proven ability to build and lead a team
• Proven ability to perform top quality scientific experimentation including processes and quality assurance
• Experience and expertise in promoter discovery, gene regulation and/or transgene innovation
• Gene therapy experience a plus.
• Experience in retina, eye, neuroscience a plus
• Regulatory and health authority experience a plus.
Skills:

• Innovative, accomplished scientific thinking
• Strong leadership skills including team building and retention
• Strong scientific understanding and knowledge of the drug development process
• Ability to strategize, problem solve, analyze, critique, assess and present research data
• Confident and respectful when interacting with all levels of management; stays focused and on-point, and raises problems or challenges in a productive, solution-minded manner.
• Ability to prioritize programmatic needs, highly adaptable, professional with the ability to deliver successful programs
• Strong interpersonal skills and professional demeanor.
Physical Requirements:

• Location: Bay Area location preferred with regular requirement to be on site for team meetings during the COVID pandemic period
• Adhere to 4DMT Covid protocols and policy including providing proof of current vaccination status to work on-site

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

About 4DMT:
4D Molecular Therapeutics, Inc. (“4DMT”) is a clinical-stage gene therapy company pioneering the development of product candidates using targeted and evolved AAV vectors. 4DMT seeks to unlock the full potential of gene therapy using its platform, Therapeutic Vector Evolution, which combines the power of directed evolution with approximately one billion synthetic capsid sequences to invent evolved vectors for use in targeted gene therapy products. The company is initially focused on three therapeutic areas: ophthalmology, cardiology, and pulmonology. The 4DMT targeted and evolved vectors are invented with the goal of being delivered through clinically routine, well-tolerated, and minimally invasive routes of administration, transducing diseased cells in target tissues efficiently, having reduced immunogenicity, and, where relevant, having resistance to pre-existing antibodies.

Attention: Search Firms / 3rd Party Recruitment Agencies*
The Talent Acquisition / HR team manages the recruiting for all positions at 4D Molecular Therapeutics. We will only accept resumes from a search agency/recruiter if we have a signed agreement in place and the Talent Acquisition / HR team has formally requested your help on a specific role. Unsolicited resumes sent to 4D Molecular Therapeutics will be considered property of 4D Molecular Therapeutics. 4D Molecular Therapeutics will not be responsible for any fees associated should we hire from unsolicited resumes.

Recruiters are requested not to contact or present candidates directly to our hiring managers or employees, and doing so may jeopardize eligibility to work on future positions. Recruiters interested in working with 4D Molecular Therapeutics can submit their information to recruiting@4dmt.com– should we have a tough-to-fill role, we will contact you directly if you specialize in that area.