Intellia Therapeutics

Senior Scientist, AAV Analytical Development

Cambridge, MA
Dec 04, 2021
Required Education
Bachelors Degree
Position Type
Full time

Why Join Intellia? 

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. 

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. 

We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.   

How you will Achieve More with Intellia:

As a Senior Scientist, you will join our AAV analytical development team within the Technical Operations group and embrace the opportunity to transform amazing sciences and technologies into powerful cures. You will be responsible for evaluating and implementing new and existing analytical methods to support AAV process development including but not limited to AUC, DLS, cIEF, SEC-MALS, AF4, and CE-SDS. Main responsibilities also include:

  • Functions independently as a technical expert in AAV-related chromatography method development, execution, and troubleshooting.

  • Coordinate product characterization, support stability, and in-process testing of AAV, and other biological molecules.

  • Represent AD in AAV-related early and Late Stage CMC activities.

  • GMP manufacturing: participate in the support of analytical activities at CMOs and CTOs related to analytics including method qualification and validation, data trending, troubleshooting, optimization, review, and reporting

  • Participate in BLA-enabling activities including product and process characterization, comparability studies, CQA assessment activities

About you:

Are you interested in this amazing virus called AAV? Are you skilled in analytical method development focused on AAV? If you say yes, we encourage you to apply! Other qualifications and desired skills include:

  • Bachelor’s degree in Chemistry, Biology, or related area with 10 – 12 years of hands-on industrial experience, or master’s degree with 6-8 years, or Ph.D. with 2 – 4 years.

  • Proficiency with analytical assays including HPLC, AUC, DLS, CE-SDS is required.

  • Experience with method development for viral vectors is a plus.

  • Experience with other analytical assays including ddPCR/qPCR and ELISA and cell-based transduction assay is a plus.

  • Experience managing people is a plus.

  • Organized, detail-oriented, and demonstrated independent thinker who continuously seeks innovative solutions.

  • Excellent verbal and written communication, teamwork, and strong problem-solving skills.

Meet your future team:

The Analytical Development team is a group of Energetic, Brilliant, Fun, and Motivated individuals. We work on different modalities and still work as a team to achieve our goals. We are a small but growing family. This group is responsible for developing robust and innovative analytical methods to support internal and external manufacturing processes. We support Intellia’s clinical programs as well as in vivo and ex vivo emerging pipelines. While much of the day-to-day operations require wet-lab work, our team focuses on not only building everyone’s technical expertise but also fostering an environment for career growth as scientists and engineers in the biopharmaceutical industry.

You will report to the Associate Director, AAV Analytical Development. He oversees Chromatography, Mass Spectrometry, and Biophysical functions. He loves to see people grow and develop and look forward to learning from your experiences and building the team together with you.

Covid-19 Vaccination Policy: Effective Monday, January 3, 2022, all Intellia employees, regardless of work location, must be fully vaccinated for COVID-19. Requests for exemption for medical or sincerely held religious beliefs will be considered.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.