Senior Scientist I/II

About AbbVie
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company with a mission to develop innovative therapies to address the world's most complex and serious diseases. AbbVie employs approximately 47,000 people worldwide and markets medicines in more than 175 countries. 

The AbbVie portfolio consists of several marketed products in areas including eye-care, Immunology, Oncology, Virology, and Women’s Health as well as a pipeline containing multiple promising new molecules being studied in hundreds of clinical trials or advancing from Discovery into Development. AbbVie is a global organization with US research sites in Boston (Worcester, MA), Chicago (North Chicago, IL), and the San Francisco Bay Area.

The Drug Metabolism, Pharmacokinetics, and Bioanalysis (DMPK-BA) group is searching for  a project representative in South San Francisco to provide small molecule project support for oncology discovery. The position requires close collaboration with Discovery project teams and other stakeholders, developing and executing DMPK strategies necessary to select and facilitate the advancement of optimized candidate molecules.

Key Responsibilities:

• Develop and drive the DMPK-BA project strategy for discovery projects to support decisions and milestone transitions 
• Serve as a DMPK-BA representative on project teams and collaborate with project team members (e.g., Discovery, Pre-clinical Safety) and groups within DMPK-BA to generate relevant data to support compound selection and progression.
• Effectively communicate DMPK-BA strategy and knowledge to project teams, functional leaders, and other key stakeholders to ensure alignment and influence decisions
• Demonstrate thorough understanding of the DMPK-BA aspects necessary for the characterization of modalities to support regulatory submissions.
• Coordinate and request DMPK-BA studies in a timely manner and communicate protocols, timelines, needs and results back to team, ensuring optimized cycle times
• Serve as a liaison with bioanalytical groups to ensure timely reagent generation, method development and sample analysis
• Prepare DMPK-BA sections of regulatory documents (IB, IND, BLA, NDA); provide responses to regulatory questions and ensure generation of appropriate reports

Qualifications

Qualifications:

• Bachelor with extensive (at least 10-12 years) experience, Masters with substantial (at least 8-10 years) experience, or Doctorate (Ph.D.) with at least 0-4 years of experience in the pharmaceutical or biotechnology industrie
• Experience independently representing DMPK on small molecule project teams is preferred
• Experience in the field of DMPK with a general understanding of one or more disciplines within DMPK and knowledgeable in one or more of the following areas: in vitro ADME, pharmacokinetics, transporter, DDI, translational modeling, biotransformation, biomarker strategy
• Experience with PK analysis of small molecules and relevant data analysis software such as Phoenix/WinNonlin is a plus
• Demonstrated publication record; lead/senior author contributions a plus
• Ability to influence, negotiate and communicate effectively with both internal and external stakeholders; ability to work well in a collaborative fast-paced team environment
• Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as team player and project driver
• High degree of flexibility in adapting to different projects and people; excellent networking and relationship-building (both internal and external) skills
• Passion for data analysis, solving technical problems and applying new technologies to further scientific goals
• Level and compensation will be commensurate with experience
• Equal Opportunity Employer Minorities/Women/Veterans/Disabled 

Key Leadership Competencies:

• Builds strong relationships with peers and cross-functionally with partners outside of team to enable higher performance
• Learns fast, grasps the "essence" and can change course quickly where indicated
• Raises the bar and is never satisfied with the status quo
• Creates a learning environment, open to suggestions and experimentation for improvement
• Embraces the ideas of others, nurtures innovation and manages innovation to reality

Significant Work Activities
Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)
Travel
No
Job Type
Experienced
Schedule
Full-time
Job Level Code
IC
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.