PKDM Scientist, ADME Scientist, Large Molecule Therapeutics

South San Francisco, CA
Dec 02, 2021
Required Education
Masters Degree/MBA
Position Type
Full time


Youve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge youve worked hard to acquire and the passion you already have. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

PKDM Scientist


What you will do

Lets do this. Lets change the world. In this vital role you will be involved in the discovery and development of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion (ADME) and pharmacokinetic properties of novel therapeutic drug candidates to improve their pharmacological potential.

PKDM works in close partnership with disciplines such as protein science, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to engineer promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.


  • Design and execute biological and/or biophysical experiments to understand the ADME properties of large molecule therapeutics (and non-traditional small molecule therapies) in support of both drug discovery and early development programs.
  • This is a lab-based role, with an emphasis on assay/technology development for the purposes of defining mechanism of in vivo clearance and/or biodistribution processes.
  • Requires an understanding of preclinical ADME and bioanalytical techniques and an individual that can work collaboratively in a fast-paced work environment.
  • Other responsibilities include data interpretation and communication of results to project team representatives and electronic laboratory notebook keeping of results.
  • Be responsible for developing and executing department strategy for drug candidate teams as a PKDM project representative.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Scientific professional we seek is a leader with these qualifications.

Basic Qualifications
  • Masters degree with 5 years of experience
  • Doctorate degree with 3 years of experience
Preferred Qualifications
  • PhD or MS in immunology, biochemistry, biophysics, or equivalent.
  • 2+ years of protein therapeutics drug discovery and development experience in biotech
  • industry, basic understanding of protein therapeutics pharmacokinetics.
  • Expertise, and a strong interest in evaluating protein-protein interactions using modern biophysical analytic techniques.
  • Expertise in protein biochemistry techniques, including reagent preparation, assay development, optimization and troubleshooting.
  • Experience translating biochemical and biophysical observations and phenomena into relevant cellular and animal-based models with mechanistic insights is desirable.
  • Proficiency with Watson-LIMS data analysis software is desirable.
  • Excellent communication and interpersonal skills and the ability and interest to learn and deliver results in a fast-paced, demanding environment.

Some of the vast rewards of working here

As we work to develop treatments that take care of others, so we work to care for our teammates professional and personal growth and well-being.

  • Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey
  • A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
  • Generous Total Rewards Plancomprising health, finance and wealth, work/life balance, and career benefitswith compensation and benefits rated above 4 stars (out of 5) on Glassdoor
Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

Amgen requires all staff in the United States and Puerto Rico to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.