Scientist / Senior Scientist, Functional Genomics

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a highly motivated and innovative scientist to help develop and expand our functional genomics platform and contribute to multiple therapeutic discovery programs. The successful candidate will be able to lead new technology development from the bench and through computational analysis. As part of the early research group at Maze, this person will have the opportunity to play a key role in multiple target discovery programs – with a particular emphasis on therapies that modify RNA regulation. This role will involve close collaboration with data scientists, geneticists, automation engineers, disease biologists and our Drug Discovery team.

Your Role in Navigating the Maze:

• As a member of the Functional Genomics team, you will apply a variety of cutting-edge screening techniques to better understand target/disease mechanisms
• Active involvement in analyzing large datasets individually and in collaboration with our Data Science team
• Develop strategies for hit follow-up and target validation in collaboration with our Human Genetics and therapeutic area teams
• Champion ideas for new target discovery and technology development projects
• Communicate data and scientific results to both internal and external audiences with a high degree of sophistication

Your Navigation Tools:

• PhD with at least 3-8 years of relevant experience in a pharmaceutical, biotechnology, or academic setting or MS with several years of relevant industry experience
• Broad laboratory skills in molecular and cell biology. Expertise with several of the following: cell-based assay development, CRISPR/CRISPRi/CRISPRa screening, library assembly, cell engineering, next-gen sequencing, single cell methods
• Familiarity with computational methods for analysis of sequencing, functional genomics, or other high-complexity datasets.
• Experience with R, Python, Matlab, or other programming languages
• The ideal candidate will have significant experience studying RNA regulatory mechanisms, including some subset of:
  • RNA processing / splicing
  • mRNA stability, translation and degradation
  • RNA-protein interactions
  • Keen motivation to develop new technologies and enthusiasm to bring new scientific capabilities into Maze
  • Outstanding communication, collaboration, and project management skills  

• Track record of mentoring and developing associates is a plus
• A positive disposition and “can-do” attitude with motivation to break scientific barriers