Bioinformatics Scientist

GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by developing pioneering technology to detect and identify multiple deadly cancer types early. The company is using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop its multi-cancer early detection blood test. GRAIL is headquartered in Menlo Park, CA with locations in Washington, D.C., North Carolina, and the United Kingdom. GRAIL, LLC is a wholly-owned subsidiary of Illumina, Inc. (NASDAQ:ILMN). For more information, please visit www.grail.com.

 In this role, you will analyze some of the largest, richest biological datasets in the world to find biological signals and patterns and guide our assays, bioinformatics pipelines, and product strategies. Working closely with scientists, clinicians, and engineers, you will develop inference algorithms and tools to investigate the biology of tumor-derived cell-free DNA, and how that relates to classification performance. You will execute statistical analyses operating across GRAIL’s data sets, public data, and data from collaborators in academia and industry. Your analyses will result in exciting discoveries in cancer biology, impactful publications, and products for the early detection of cancer. You will be in a position to help ensure GRAIL protects the information we receive as part of our mission to help detect cancer! 
You Will:

• Modeling and analysis of large, complex genomics datasets using machine learning and statistical methods to generate biological insights. 
• Perform end-to-end analysis that include data gathering, processing, analysis, iteration with stakeholders, and presentation of results.
• Interact cross-functionally with other teams including software, clinical, operations, research, product development, and external collaborators.
• Promulgate analyses that reinforce scientific rigor and quality and which maintain GRAIL’s statistical culture.

Your Background Includes:

• Ph.D. in Bioinformatics, Computational Biology, Statistics, Biological Sciences, Cancer Biology, Genetics, Genomics, Computer Science, Physics, or equivalent preparation and experience.
• Proven track record of strong contributions demonstrated by highly cited publications, impactful tools, products, or data sets used by the scientific community, presentations at international conferences, and awards.
• Preferred, 3 years relevant experience in positions of increasing responsibility.
• Deep understanding of modern statistical and machine learning tools for analysis of genomics datasets. 
• Demonstrated ability to apply these skills to uncover new biological insights from large genomics datasets.
• Demonstrated expertise in at least one programming language (R, Python, Go, C++), proficiency in Linux environment, version control tools, and reproducible research practices. 
• Self-direction, willingness to both teach others and learn new techniques.
• Effective written and verbal communication skills.

GRAIL is an Equal Employment Office and Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status. We will reasonably accommodate all individuals with disabilities so that they can participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, GRAIL has made the decision to require all U.S. employees receive the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.