Senior Scientist/Project Leader, Lead Discovery

Senior Scientist/Project Leader, Lead Discovery

The Position:

Bolt’s Target Validation / Translational Sciences team seeks an innovative scientist for the discovery of Immune-stimulating Antibody Conjugates (ISACs) for cancer. You will have broad responsibility for lead candidate selection, through antibody characterization and ISAC evaluation in primary immune cell assays, and you will lead pre-clinical project teams through proof-of-concept studies. As a member of a fast-paced, collaborative team, you will play a key strategic role in building Bolt’s industry-leading ISAC pipeline. Additionally, you will work closely with external partners to define project workflows and to diversify Bolt’s portfolio.

About You:

You have a Ph.D. in immunology, cancer biology, or a related discipline. You have worked as a research scientist in drug discovery industry settings for 5 – 8 years, preferably in team settings in oncology drug development. You are driven to leverage your interests and training to bring novel molecules to patients in need. You aim to grow into a strategic leadership role.

Among your technical / scientific skills are:

Key Responsibilities:

• Design and execution of cellular assays to profile immune function (including ADCP and myeloid-tumor co-culture models) using flow cytometry and ELISA-based techniques
• Design and analysis of PK/PD/efficacy studies in rodent tumor models
• Isolation, characterization, and culture of primary immune cells
• Analyzing novel antibodies for lead selection using flow cytometry and protein binding assays
• Proficiency in data analysis and visualization software such as Excel, Prism, and FlowJo
• Proficiency in immunoblotting, ELISA (MSD or Luminex based multiplexing a plus), and gene expression assays (DNA/RNA isolation, PCR, rt PCR)
• As an integral member of cross-functional teams involving program leads, CROs, and external partners, oversees and contributes to planning, execution, analysis and reporting of gene therapy PK/PD assessments in preclinical cell-based and in vivo rodent/ studies by a team of scientists.
• Hands-on experience with mouse tumor models is a plus

Job Requirements:

• Experience as a key member of multi-functional teams, in which you delivered critical-path data within tight project timelines
• Keen focus on program priorities and a resistance to distraction
• Ability to plan, execute, and interpret a series of studies with minimal supervision
• Aptitude for presentations at different levels, from project teams to senior leadership
• Mentorship of junior staff

Who We Are:

Bolt Biotherapeutics, based in the San Francisco Bay Area, is a clinical-stage biotechnology company developing Boltbody™ Immune-stimulating Antibody Conjugates (ISACs), a new class of immuno-oncology therapeutics that have eliminated tumors following systemic administration in preclinical studies while also developing immunological memory, which may lead to more durable clinical responses for patients. This is a unique opportunity to join and build, with likeminded colleagues, a company that will transform the lives of individuals with cancers.