Senior Research Associate, Analytical Development

Company Overview:

Janux Therapeutics is a biotechnology company based in San Diego that is leveraging an innovative and proprietary platform to efficiently develop tumor activated therapeutics that attack and kill cancer. These protein biologics empower the immune system to fight cancer without destroying the patient’s healthy tissues. Janux is looking for an energetic and talented Sr Research Associate, Analytical Development with a desire to work in a rapidly growing and fast-paced cross functional team environment. We believe that the whole team contributes to the overall mission. We succeed as a team, and we grow as a team!

Sr Research Associate, Analytical Development

We are seeking a Sr Research Associate to participate in design, execution, and analysis of LC, CE-SDS, CIEF, LC-MS and capillary CE-SDS ELISA based experiments to support CMC activities and the discovery and pre-clinical development of exiting new lead candidates. Your contribution will directly support the generation of the next generation of immune oncology drugs. This position is hands-on and requires effective communication and documentation of results that enable the advancement of novel research molecules toward development and clinical candidates and ultimately into late-stage development and commercial. Ideal applicants will be highly driven, collaborative and team-oriented, possess excellent communication and organizational skills, and carry a strong commitment to excellence.

Experience Requirements

• A minimum of a bachelor’s degree and 4-6 years of relevant industry experience or a master’s degree with 3-5 years of relevant industry experience. 
• Strong benchtop skills, experienced with analysis of protein biologics and peptides.
• Proficient with the development of HPLC and UPLC assays with at least 3 years of experience is required. Assays exploiting SEC, RP, HIC and IEX chemistries. 
• Experience with capillary CE-SDS ELISA (Simple Western) blotting or similar technology desired.
• Experience with formulation development and analysis of antibodies or bispecifics is preferred. 
• Ability to perform routine testing and to follow SOPs in a highly accurate and reproducible manner.
• Basic experience with performing LC-MS and LC-MS/MS assays highly desired.
• Familiarity with Agilent OpenLab and MassHunter is a bonus, but not required.
• Ability to learn new technologies, thinking outside the box and exploring new approaches to innovate. 
• Training on project specific assays and ability to train others.
• Proven experience with writing and maintaining SOPs, ability to teach others and to transfer methods to external partners.
• Ability to work independently; takes innovative to solve problems.
• Must have excellent computer skills, proficiency with Microsoft Excel and PowerPoint required.
• Good oral and written communication skills a must, excellent team player.

Responsibilities

• Develop and perform HPLC and UPLC assays with minimal supervision including SEC, IEX, RP.
• Optimize and perform multiplexed capillary CE-SDS ELISA experiments with the Simple Western platform.
• Perform purity and quantitative assays to support formulation development, CMC and research activities in house and at partner organizations.
• Design, conduct, analyze, interpret, and report laboratory experiments, summarizes results for meetings and regulatory filings.
• Support stability, formulation, impurity characterization and in-use studies with assay development; generate key data sets to support FIH studies.
• Process and analyze samples with LC-MS and LC-MS/MS. Performs immunocapture and LC-MS/MS or quantitative CE-SDS ELISA for quantitation of proteins in biological matrices.
• Write and manages SOP’s, train others and facilitate method transfer to partners and CDMOs. 
• Assist in troubleshooting and maintaining modern analytical instrumentation.
• Manage and maintain required reagents, laboratory environment, and equipment needed to carry out assignments. 
• Prepare research reports and presentations for team meetings. 
• Work closely with team leaders to complete highest priority work to reach goals and milestones. 
• Anticipate and manages issues in a proactive fashion.
• Collaborate with internal and external CDMO/CRO teams, providing support to different functional groups as needed. 

Does this sound like you? Apply now to take your first steps toward contributing to the development of next generation protein therapeutics to eliminate cancer.

Benefits:

• 401K
• Medical insurance
• Dental insurance
• Vision insurance
• Supplemental disability insurance plans
• Flexible schedule
• Life insurance
• Flexible vacation
• Incentive stock option plan
• Employee stock purchase plan

Schedule:

Monday to Friday On-Site (La Jolla, CA)

Work authorization:

United States (Required)

COVID-19 Vaccination required

Janux requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment.  As required by applicable law, Janux will consider requests for Reasonable Accommodations.

EQUAL OPPORTUNITY EMPLOYER:

Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from