Computational Scientist I/II (Genomics)
- Employer
- Frederick National Laboratory for Cancer Research
- Location
- Frederick, MD
- Start date
- Nov 28, 2021
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- Discipline
- Science/R&D, Biotechnology, Genomics
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- BioCapital
Job Details
PROGRAM DESCRIPTION
The Molecular Characterization Laboratory (MoCha) is part of Leidos Biomedical Research's Clinical Research Directorate (CRD) at the Frederick National Laboratory for Cancer Research. The MoCha Laboratory is responsible for providing high-level research in support of the NCI-Cancer Diagnostics Program (CDP) within the Division of Cancer Treatment and Diagnosis (DCTD). MoCha's major activities include development and application of genomic assay platforms for use in DCTD-sponsored national clinical trials and preclinical studies.
KEY ROLES/RESPONSIBILITIES
We are seeking an enthusiastic, creative, and collaborative computational scientist to support computational and biological related questions in assigned projects/programs:
- Develop, validate and maintain genomic analysis pipelines generated from the MoCha lab and/or collaborator(s)
- Interact with PIs to define strategies for genomic data analysis including hypothesis generation and testing of predictive biomarkers of drug response
- Provide biological interpretation of the genomic analysis to advance the understanding of cancer
- Supervise and collaborate with other bioinformatics team members to ensure the quality of work and the prioritization of projects to meet deadlines
- Be responsible for generating scientific opinions, identifying potential resources or constraints, and proposing strategies for exploiting available databases and program data generated at the molecular and cellular levels
- Interact extensively with intramural laboratories at the NIH and extramural scientists and present the findings to PIs
BASIC QUALIFICATIONS
This position may be filled at the Computational Scientist I or II level.
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
- Possession of a Doctorate degree from an accredited college or university according to the Council for Higher Education Accreditation in biomedical science/bioinformatics/math/statistics/computer-related discipline. Foreign degrees must be evaluated for U.S. equivalency
- Computational Scientist I – No work experience required with a Doctorate degree
- Computational Scientist II - a minimum of two (2) years of progressively responsible scientific and/or complex system management/bioinformatics experience
- Extensive experience in analysis of next generation sequencing (NGS) data (including quality metrics, mapping, variant calling, quantitation of gene expression and biological interpretation)
- Experience managing large datasets and computational tasks in a Linux-based high-performance computing environment and cloud environment
- Proficiency with Bash, Python, Perl, R, C/C++, and/or JAVA and bioinformatics tools and database management
- Experience with Snakemake, make, or other workflow management systems
- Strong computational/bioinformatics skills and demonstrated ability to work with scientists to deliver on objectives in defined timelines are required
- Independence, self-motivation, innovation and ability to excel in a goal-oriented, multifaceted and fast-moving team environment are required
- Experience and demonstrated success in a team-oriented environment and excellent communication skills (written and oral); ability to organize and execute multiple projects in parallel
- Must be able to obtain and maintain a security clearance
This position is essential to the success of MoCha and on-site presence in Frederick, MD and occasionally in Shady Grove (Rockville, MD) is required.
PREFERRED QUALIFICATIONS
Candidates with these desired skills will be given preferential consideration:
- Peer reviewed publications demonstrating knowledge of the biology of cancer
- Experience with Ion Torrent systems, including the Ion Reporter system
- Experience with variant review and QC control in a CLIA certified laboratory
Company
A rewarding career with global impact
Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.
Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.
We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.
Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.
Discover why joining the Frederick National Laboratory team could be the most important career step you take
- Website
- https://frederick.cancer.gov/
- Phone
- 301-846-1000
- Location
-
8560 Progress Drive
Frederick
MD
21701
US
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