Investigator 1 – Immunology

Employer
CSL Behring
Location
Cambridge, Massachusetts
Posted
Nov 27, 2021
Ref
R-152153
Discipline
Science/R&D, Immunology
Required Education
Doctorate/PHD/MD
Position Type
Full time
Job Description

Job Summary

The investigator will design and conduct immunological experiments to advance preclinical vaccines initiatives in the Research group. The investigator will focus on T cell responses to novel vaccines in the appropriate laboratory animal species, with a primary objective to quantify and characterize T cells based on antigen and epitope specificity, MHC restriction, phenotype, and functional markers of activation.

Major Responsibilities

Analysis of T cell function

  • Use existing assays and develop novel assays to examine laboratory animal T cell function in vitro and in vivo
  • Design and screen synthetic peptide libraries to identify T cell epitopes
  • Develop assay methods for investigating functionally significant T cell subsets, e.g., T follicular helper (TFH) cells, regulatory T cells (Treg), and cytolytic T cells (CTL)

Achievement of Research Objectives

  • Propose, design, and execute studies to achieve preclinical development program objectives for novel vaccines
  • Work closely with other team members and CROs to design and execute multidisciplinary studies

Documentation and presentation of scientific results

  • Prepare written study plans and experiment protocols
  • Summarize, analyze, and archive data, and prepare written reports and presentations
  • Maintain electronic lab notebooks
  • Participate in cross-functional project teams, present research results, and contribute to technical advancements and publications

Lab management

  • Maintain laboratory equipment and facilities in good order
  • Observe HSE regulations and best practices

Other job duties that may be assigned

  • Support other functions and other divisions when needed

Minimum Requirements

  • PhD in immunology or equivalent
  • 2 or more years postdoctoral training in immunology
  • Immunofluorescence and multicolor flow cytometry
  • T cell phenotype, activation, and proliferation assays
  • Single cell analysis techniques
  • Multiplex assays (e.g., Luminex, Meso Scale platforms) for soluble factors
  • Cell culture, transfection, cryopreservation
  • Advanced knowledge of mammalian innate and adaptive immunity, human and animal viruses
  • Ability to synthesize concepts from immunology and virology to develop innovative and useful experimental models and systems
  • Strong organizational, written, and oral communication skills; ability to work in a team environment
  • Basic concepts in statistics and statistical analysis
  • Facility with GraphPad Prism, Microsoft Excel and PowerPoint

Preferred requirements:

  • Human immunology assays
  • Virus infection/challenge models
  • Elispot and fluorospot assays
  • Cell enrichment and purification techniques
  • Characterization of antibody specificity and function
  • Molecular biology and protein biochemistry techniques
  • Advanced data analysis software, e.g., Spotfire

About Us

Our Benefits

Seqirus is committed to attracting and retaining world-class employees who are valued for their contributions to achieving business objectives. Learn more about some of the benefits you can participate in when you join Seqirus.

About Seqirus

Seqirus is part of CSL Limited (ASX: CSL). As one of the largest influenza vaccine providers in the world, Seqirus is a major contributor to the prevention of influenza globally and a transcontinental partner in pandemic preparedness. Learn more about Seqirus.

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