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Associate Scientist II/Sr. Associate Scientist, Upstream Pilot Plant, Protein Process Development

Employer
Vaxcyte, Inc.
Location
Palo Alto, California
Start date
Nov 25, 2021

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Job Details

Company Profile
Vaxcyte, Inc. (Nasdaq: PCVX) is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent some of the most common and deadly infectious diseases worldwide. Our exclusively licensed cell-free protein synthesis platform and our proprietary know how enable us to design and produce optimized protein carriers and antigens, the critical building blocks of vaccines, in ways that we believe conventional vaccine technologies cannot. Our lead vaccine candidate, VAX-24, is a preclinical, 24-valent broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease. Our pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of at least 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease by targeting the keystone pathogen responsible for this chronic, oral inflammatory disease. 

Summary
Vaxcyte is looking for an energetic and talented individual to start up new pilot plant capacity within our protein process development and manufacturing group.  This is an opportunity to create a new, highly impactful function within Vaxcyte.  By scaling up production of proteins for Vaxcyte’s clinical pipeline, the pilot plant will not only generate needed materials for development use, but also generate highly valuable data on process performance, consistency, scale up, and reuse.  The successful candidate will have the following skills and qualities:
An exceptional team member that fosters a highly collaborative work environment

• A confident individual who speaks up, is open to input, and remains focused on achieving the best results to achieve company goals

• A diligent scientist/engineer who enjoys process execution and scale up

• The ability to clearly present data, trend longitudinal data, draw conclusions, and communicate salient points concisely

• A strong sense of ownership and accountability; commitment to Vaxcyte’s mission
Essential Functions

    • Set up a new pilot plant production line in Vaxcyte’s new facility
    • Preparation of buffers, execution of bioreactors, and harvest operations
    • Support downstream pilot plant operations
    • Develop process records that clearly instruct and efficiently facilitate capture of data
    • Plan and manage logistics of routine pilot production of proteins to support Vaxcyte’s pipeline
    • Support scale up activities for processes as part of technology transfer to CMOs
    • Contribute to process development for protein processes as time allows
    • Run in-process tests and product quality assays to support pilot production
    • Participate in technology transfer activities for the process developed at Vaxcyte to an external CMO for GMP production
    • All Vaxcyte employees require vaccination against COVID-19

Requirements
    • BSinChemicalEngineering,Biochemistry,orarelateddiscipline,with5+yearsofindustryexperience
    • Experience with setup and operation of bioreactors
    • Theoretical understanding of cell culture processes and cell-free protein synthesis
    • Proficiency running analytical methods a plus; such methods may include SDS-PAGE, Endosafe, UV spectroscopy, and HPLC
    • Experience with harvest technology such as depth filtration, flocculation, and centrifugation
    • Experience with Benchling ELN is a plus
    • Strong interpersonal skills, with excellent written and verbal communication skills

Reports to: Staff Scientist, Protein Process Development and Manufacturing
 
Location: San Carlos, CA
 
Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component.

Vaxcyte, Inc.
825 Industrial Rd.
Suite 300, San Carlos, CA 94070

Company

Vaxcyte, Inc. (Nasdaq: PCVX) is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent some of the most common and deadly infectious diseases worldwide. Our exclusively licensed cell-free protein synthesis platform and our proprietary know how enable us to design and produce optimized protein carriers and antigens, the critical building blocks of vaccines, in ways that we believe conventional vaccine technologies cannot. Our lead vaccine candidate, VAX-24, is a preclinical, 24-valent broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease. Our pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of at least 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease by targeting the keystone pathogen responsible for this chronic, oral inflammatory disease.

Company info
Website
Phone
(650) 837-0111
Location
825 Industrial Road, Suite 300
San Carlos
CA
94070
US

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