Research Associate/Senior RA, DNA Encoded Scientist, Library Discovery

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

About the Position

We are seeking a talented and highly motivated scientist to join our Library Discovery team and help us augment our DNA encoded library collection. DEL synthesis is an interdisciplinary process that utilizes molecular biology techniques and applied them toward chemistry problems.  Prior knowledge of modern biological methods and basic knowledge of laboratory organic chemistry is a plus, but the most important attributes are an eagerness to learn and a strong work ethic.  As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

Qualifications

• BS or MS in life sciences (ex. biology, chemistry, biochemistry) with 0-2 years industrial experience
• Training in modern molecular biology techniques
• Willingness to ask questions and strong drive to succeed
• High level of creativity and productivity with strong problem-solving skills.
• High level of attention to detail and good organizational skills.
• Excellent communication skills

Fit with Nurix Culture and Values

• Strongly team-oriented; highly collaborative
• Hands-on approach; resourceful and open to diverse points of view