Principal Scientist - Therapeutic Protein Characterization and Predictive Analytics

.

HOW MIGHT YOU DEFY IMAGINATION?

If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. Its time for a career you can be proud of. Join us.

Principal Scientist - Therapeutic Protein Characterization and Predictive AnalyticsLive

What you will do

Lets do this. Lets change the world. We are seeking a scientist and analytical protein chemist with a consistent track record in biopharmaceutical protein support, scientific eminence and leadership and mentoring skills.

In this vital role you will be part of the Discovery Attribute Sciences group providing scientific and technical expertise to support early discovery research through to later stage molecule optimization and late-stage selection of Amgens pipeline of drug candidates. This position is an exciting opportunity to unlock the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics.

• Experience managing timelines and therapeutic projects
• Experience managing other analytical chemists
• Experience using analytical characterization techniques such as rpLC-MS, native-MS, capillary electrophoresis (and CE-MS), cation exchange (and CEX-MS), size exclusion chromatography (and SEC-MS) and biophysical techniques including, but not limited to hydrophobic interaction chromatography, differential scanning and fluorometric calorimetry, self-interaction spectroscopy and rheology.
• Experience with rpLC-MS/MS to map and characterize post translational modifications such as deamidation, isomerization and oxidation
• Experience generating, processing and using large analytical data sets for the application of biomolecule attribute and manufacturability prediction.
• Experience using sensitive high-throughput, low material consumptive and predictive analytics would be an advantage
• Develop collaborations with both internal and external partners. For example, clients in early research protein cloning, expression and purification; process development; university and external research institutes
• Communicate (verbal and in written) scientific concepts and results
• Work collaboratively with other scientists on multidisciplinary teams
• Work independently in advancing projects and studies within required deadlines
• Actively create or contribute to patent and publications
• Keep current with field of expertise, participate and advance drug development, technologies and information services programs within Amgen
• Demonstrate external scientific eminence in the form of peer-reviewed publications and conference presentations
• Follow protocols and procedures, maintain accurate records in an electronic lab notebook, and generate quality data for use in drug development and regulatory filings

Win

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a scientist with these qualifications.

Basic Qualifications

Doctorate degree and 3 years of biopharmaceutical Analytical Chemistry, Biochemistry or equivalent experience

Or

Masters degree and 6 years of biopharmaceutical Analytical Chemistry, Biochemistry or equivalent

Or

Bachelors degree and 8 years of biopharmaceutical Analytical Chemistry, Biochemistry or equivalent

Preferred Qualifications

• Educational emphasis in analytical characterization and predictive techniques to assess protein purity, molecular weight, stoichiometry, post-translational modifications, stability and manufacturability would be an advantage. Relevant experience working as part of a multidisciplinary team in a biopharmaceutical setting would also be an advantage.
• Knowledge of statistical processing of data, including related software like RStudio and Jupyter Notebooks Excel, Spotfire, JMP or ArrayStudio
• Knowledge of multiple mass spectrometric (MassLynx, MassHunter, XCalibur) chromatographic (ChemStation, Chromeleon), Astra (SEC-MALS/QELLS), Tecan scripts (automation), TA and NanoTemper (calorimetry) software would be advantageous

Thrive

Some of the vast rewards of working here

As we work to develop treatments that take care of others, so we work to care for our teammates professional and personal growth and well-being.

• Full support and career-development resources to expand your skills, enhance your expertise, and increase your potential along your career journey
• A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
• Generous Total Rewards Plancomprising health, finance and wealth, work/life balance, and career benefitswith compensation and benefits rated above 4 stars (out of 5) on Glassdoor

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

careers.amgen.com
Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen requires all staff in the United States and Puerto Rico to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.