Principal Scientist

Sanofi US
02451, Waltham
Nov 23, 2021
Required Education
Position Type
Full time

Description: Sanofi is seeking an energetic and self-motivated scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) research platform of the North American Hub. As a member of the DMPK department you will join a team of DMPK scientists to support the discovery projects in the therapeutic areas of Rare and Neuro Diseases, Rare Blood Disorders, Immunology and Inflammation, and Immuno-oncology.

Key Responsibilities:

Evaluate and monitor in vitro ADME outsourcing activities at CROs, including but not limited to metabolism, protein binding, tissue partitioning, and drug-drug interaction. Perform complex data analysis for interpreting ADME properties for establishing in vitro-in vivo correlations and translation to human. Manage CROs for in vitro assays to characterize enzyme kinetics, reaction phenotyping, and drug-drug interaction potential for potential small molecule clinical candidates. Develop and execute novel cell-based assays to investigate non-routine issues when applicable. Develop tools and design in vivo experiments to enable the investigation of ADME related project issues. Promote innovative approaches for the advancement of drug candidates across various modalities including small molecules, RNA, and biotherapeutics. Approaches to innovative computational ADME is a plus.

The role also includes the review of reports generated from CROs and the preparation of study reports for regulatory submissions. Highly qualified candidates may also be provided the opportunity to represent DMPK on project teams.

Basic Requirements:

  • A Ph.D. in Drug Metabolism or Pharmacokinetics with 5+ years of relevant post-graduate experience.

  • Ability to independently conduct in vitro ADME studies, propose and/or generate new tools to address metabolism and other ADME issues.

  • Extensive knowledge of drug metabolism and pharmacokinetics in a research setting.

  • Ability to keep current with literature and report scientific data in a public forum.

  • Ability to initiate and implement new research ideas. Summarize research results into scientific presentation and manuscript.

  • Demonstrate strong written and verbal communication skills and have a solid scientific publication record.

  • Able to work in a collaborative environment and contribute to high scientific rigor.

  • Demonstrate ability to work in a matrix environment and in a global environment.

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.


At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.