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Sr R&D Specialist, Immuno-Oncology

Employer
Regeneron Pharmaceuticals, Inc.
Location
Tarrytown, New York
Start date
Nov 22, 2021

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Discipline
Clinical, Clinical Medicine, Science/R&D, Bioengineering
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Pharm Country

Job Details

We are seeking a Senior R&D Specialist to join the human anti-tumor immunology research group in Oncology Research. This individual will work on a team that develops and performs phenotypic and functional assays on patient samples. The work will support clinical immune monitoring and exploratory assays on clinical biomarker samples collected from patients who are receiving Regeneron’s cancer therapies. Some key goals of the work are to understand how our cancer therapies are working in the patients. As well as to identify features of anti-tumor immune responses, and study mechanisms of immune evasion.

As a Senior R&D Specialist in the anti-tumor T cell biology team, a typical day might include the following: 

-  Independently design high-paramter flow cytometry panels 

-  Operate high-parameter flow cytometers (BD Symphony and CyTek Aurora preferred) and perform subsequent data analysis

-  Isolate immune cells from human tissues for phenotypic and functional characterization

-  Isolate PBMC from human peripheral blood, perform downstream cell enrichment and in vitro culture

-  Independently develop and execute primary human immune cell functional assays

-  Adapt primary cells for in vitro culture and downstream assays

-  Perform primary human immune cell and tumor cell co-cultures 

-  Perform high-throughput T cell screening to determine antigen-TCR pairing

This role may be for you if:


-  You can work both independently and collaboratively with other internal research and clinical teams to jointly develop and advance technology-forward methods to evaluate human anti-tumor T cell function

-  You are experienced in methods of human immune cell culture and functional assays

-  You are an independent thinker and have problem-solving abilities

To be considered for this position, you must have MS and 6 + years of experience or BSc + 8 years of experience in Molecular Biology, Immunology or related field, and experience in T cell biology and/or cancer biology. We need an individual with a strong background in one or more areas of tumor biology, immunology, and/or immuno-oncology. The position requires experience in high-parameter flow cytometry (25-40+ color). We are looking for a candidate with experience in tissue culture, with preference for primary cell culture experience, and hands-on technical experience in molecular and cell biology in the oncology field is required. Strong written and oral communication skills are required. We are seeking prior experience with high-throughput immunological screening and single cell sequencing including TCR sequencing. Proven ability to maintain experimental documentation, performing data analysis independently, organizing and presenting data at internal group meetings

This position will require the individual to pass a physical before beginning employment. 

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels! 

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

#REGNCYTO

Company

Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to seven FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye disease, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, infectious diseases, pain and rare diseases.
 
Regeneron is accelerating and improving the traditional drug development process through our proprietary VelociSuite® technologies, such as VelocImmune® which produces optimized fully-human antibodies, and ambitious research initiatives such as the Regeneron Genetics Center, which is conducting one of the largest genetics sequencing efforts in the world.

Stock Symbol: REGN

Stock Exchange: NASDAQ

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Company info
Website
Phone
914-847-7000
Location
Corporate Headquarters
777 Old Saw Mill River Road
Tarrytown
New York
10591
United States

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