Lead Scientist, Structural Biology

Location
Brisbane, CA
Posted
Nov 18, 2021
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
OPPORTUNITY
Mammoth’s Discovery Team is seeking a Lead Scientist to establish and lead structural biology and engineering of CRISPR-associated (Cas) nucleases for therapeutic genome editing applications. Discovery is a cross-disciplinary team of researchers responsible for the identification, screening and optimization of novel Cas nucleases. The successful candidate will be positioned in a downstream role within the team and will be responsible for pushing Cas nucleases into pre-clinical applications. A strong background in structural biology (X-ray crystallography and/or cryo-EM) and structure-guided protein engineering is required for this role. 

KEY RESPONSIBILITIES
  • Lead structural biology and rational protein engineering efforts at Mammoth
  • Manage external collaborations to support protein production and structural studies (CROs, academia)
  • Prepare protein, RNA, and/or DNA reagents and ensure quality specifications are met
  • Utilize computational and experimental approaches to design, produce, and evaluate engineered Cas nucleases for improved or altered activities
  • Document results and provide updates to key stakeholders


REQUIRED QUALIFICATIONS
  • PhD in structural biology, molecular biology, synthetic biology or a related field
  • 6+ years experience designing, executing, and optimizing protein structural studies (X-ray crystallography and/or cryo-EM)
  • Demonstrated experience utilizing structure-informed engineering approaches to improve or alter the functionalities of proteins and/or RNAs (Eg. Rosetta, AlphaFold)
  • Computer and scripting skills (Benchling, Geneious, JMP, SQL, R, Python)


PREFERRED QUALIFICATIONS
  • 3+ years biotechnology industry experience
  • Prior experience initiating and managing external collaborations in industry
  • Expertise in solving and analyzing the 3-D structures of nucleic-acid interacting proteins
  • Familiarity with CRISPR-Cas literature
  • Demonstrated ability to independently design and execute NGS assays
  • Hands-on experience with mammalian tissue culture and transfection
  • Ability to perform at a high level as a member of a cross-functional team

BENEFITS
  • Company-paid health/vision/dental benefits
  • Unlimited vacation and generous sick time
  • Company-sponsored meals and snacks
  • Wellness, caregiver and ergonomics benefits
  • 401(k) with company matching


Mammoth Biosciences is harnessing the diversity of life to power the next generation of CRISPR products. Through the discovery and engineering of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to develop permanent genetic cures through best-in-class in vivo and ex vivo therapies and to democratize disease detection with on-demand diagnostics. Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Redmile Group, Foresite Capital, Senator Investment Group, Sixth Street, Decheng, Mayfield, NFX, and 8VC, along with leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.

TEAM
Our small-size proteins, such as Cas14 and CasPhi, are poised to transform disease treatment enabling novel editing approaches and delivery options that are difficult to achieve or not even possible with previously described CRISPR-Cas systems. Our teams are responsible for discovering and engineering novel CRISPR systems, establishing CRISPR-based diagnostics, and translating our unique CRISPR technology into therapeutic treatments with the ultimate goal of cures for indications with high medical need.

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