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Scientist II, Senior Scientist, or Principal Scientist

Employer
Dren Bio
Location
Bay Area
Start date
Nov 18, 2021

View more

Discipline
Science/R&D, Biotechnology, Research, Immunology, Molecular Biology
Required Education
Bachelors Degree
Position Type
Full time

About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct drug discovery programs. The Company’s first program surrounds DR-01, its lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program surrounds its Targeted Myeloid Engager and Phagocytosis Platform, a proprietary bispecific antibody-based technology that provides for a novel mechanism of action to selectively engage myeloid cells for (1) targeted depletion of pathologic cells and other disease-inducing agents and (2) inducing localized immunostimulation. The engagement of antigen presenting cells has the potential to elicit a sustained, durable response.

Function:

Biologics Discovery

Level:

Senior Scientist, or Principal Scientist based on experience

Location:

Redwood City, CA

Reporting Manager:

Associate Director, Biologics Discovery

About the Opportunity:

Dren Bio is seeking a bright, highly motivated, and experienced scientist to join the Biologics Group. The Biologics group is responsible for various functions critical for drug development such as: antibody discovery, molecular biology, cell line engineering, protein engineering, biophysical analytics, and functional cell assays. This position will need to bridge biology and protein understanding to drive projects from early exploratory work to clinical POC for the myeloid engager platform in a cross-functional team of scientists.

Role and Responsibilities:

  • Lead protein engineering efforts, demonstrating flexibility, and enthusiasm to support evolving company goals that are inherent of a fast paced startup environment
  • Collaborate with project team to drive POC experiments, and develop MOA understanding for drug candidate.
  • Present updates and novel concepts to the wider team.
  • Contribute to patents and publications.
  • Strong analytical and critical thinking skills with the ability to interpret complex data and highly motivated to learn and support the drug development efforts
  • Routine literature search and keeping up to date of the competitive landscape of immunooncology, and various moieties being designed as next generation drugs.
  • Motivated self starter who can work independently and collaboratively in a dynamic team environment with a proactive attitude
  • Excellent written and verbal communication skills
  • Ability to work in a fast paced environment and the flexibility to align daily work with project needs
  • Ability to set goals and prioritize tasks and resources to achieve superior work quality and efficiency
  • Must be well organized, have a strong work ethic, attention to detail and be diligent in data documentation

Education, Experience and Qualification Requirements:

  • Bachelors or Masters in immunology, molecular biology, or related field (10+ years of experience)
  • PhD in Cancer Biology, Biochemistry, or related discipline with approximately 0-5 years of experience in academia or biopharmaceutical industry.
  • Demonstrated record of scientific know how and accomplishments (publication and patents)

Core Competencies, Knowledge and Skill Requirements:

  • Understanding of structure-function protein relationship to guide protein engineering
  • Antibody discovery (animal immunization, phage and/or yeast display)
  • Protein chemistry (mol. biology, expression, purification, biophysical analytics)
  • Analytical characterization of antibody based moieties (SEC, HPLC, CE-SDS, Biosensor)
  • Ability analyze protein via structures and sequences. (Pymol, MOE, Schrodinger, ect)
  • Optimize lead antibody candidates (affinity maturation, structure guided design, or in silico analysis)
  • Understanding of immune related assays (ADCC, ADCP, antigen presentation, T Cell activation, ect)

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

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