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Senior Associate Scientist / Research Scientist, Biology

Employer
Arvinas Inc.
Location
New Haven, CT
Start date
Nov 11, 2021

View more

Discipline
Regulatory, Science/R&D, Biology, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Pharm Country

Job Details

Arvinas is a clinical-stage biopharmaceutical company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas’ PROTAC® Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas’ pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes two clinical-stage programs: ARV-110, which is being developed as a potential treatment for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being developed as a potential treatment for patients with breast cancer.

#TeamArvinas is made up of more than 200 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and purpose – to improve the well-being of patients and families impacted by the devastating diseases Arvinas is working to treat. It’s an exciting time to be in drug development and it’s an exciting time to be at Arvinas. But don’t just take our word for it – here’s what Arvinas employees are saying. For more information, please visit www.arvinas.com.

 

 

Position Summary

This position is laboratory-based, requires strong experimental skills, and the ability to effectively partner with team members to deliver high quality data in support of drug discovery projects carried out in collaboration with external strategic partners

This position reports to a Senior Research Scientist, Biology and will be located at our headquarters in New Haven, CT.

 

 

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Culture various mammalian tissues for protein purification and expression.
  • Design, validate, and execute medium- to high- throughput 96/384 well cell-based and biochemical assays (such as ELISA, In-Cell Western, capillary electrophoresis) to measure target levels, engagement and modifications in response to compound treatment or molecular modulation (e.g. RNAi).
  • Analyze, document, compile and interpret experimental data; manage laboratory notebook, databases, and/or spreadsheets to present data in a meaningful manner
  • Leverage multiple assay platforms to dissect target biology, function and pathway modulation in response to compounds or molecular modulation.
  • Interact and collaborate with biology and chemistry team members to contribute to drug discovery and program progression.

 

 

Qualifications

  • Demonstrated experience in methods for assessing protein levels in various bioassays (eg. Western blots, ELISA, In Cell Western, capillary electrophoresis.)
  • In vitro and or ex vivo mammalian tissue culture techniques
  • Various cellular functional assays (i.e. 2D/3D cellular proliferation assays/cytotoxicity/apoptosis assays/siRNA/shRNA/CRISPR knockdown assays)
  • Development and optimization of cell-based and biochemical assays using a variety of readout technologies (e.g. fluorescence, luminescence, TR-FRET, AlphaLISA)
  • Excellent data handling and recording skills as well as oral and written communication skills
  • Work as a team player and be able to multitask.  Demonstrated ability to plan experiments independently a plus.
  • Experience with protein degraders and small molecules is a plus
  • Innovative, independent, motivated and productive problem solver with excellent communication skills who also works effectively in a team setting
  • Organized, goal-oriented and timeline-conscious
  • Ability to work and problem-solve independently while under general supervision by the project leader

 

 

Education

  • BS with minimum of 5 years of relevant experience, or MS in Biology or relevant discipline with 2+ years relevant experience

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Company

At Arvinas, we’re leading the creation of an entirely new way to treat disease through therapies that target and degrade disease-related proteins. We are a clinical-stage biopharmaceutical company focused on developing new therapeutics for cancers and other difficult-to-treat diseases. Our proprietary PROTAC® protein degraders, or proteolysis-targeting chimeras, work by harnessing the body’s own natural protein disposal system to degrade and remove disease-causing proteins.

Our leading programs are focused on high-value targets in cancer, including the androgen and estrogen receptors associated with prostate and breast cancers, respectively. Our hope is to unlock the full potential of PROTAC protein degradation by developing our own robust pipeline and by partnering with the world’s leading drug development companies.

QUALITY BENEFITS
Designed with health and wellness in mind, employees and their families are eligible for:

  • Medical, dental, and vision options, including a generous company contribution into an HSA
  • Paid maternity and paternity leave
  • FSA, HSA, Healthcare, and Dependent Care accounts
  • Company provided life insurance and short/long-term disability coverage
  • Additional voluntary benefits including critical illness, hospital care and more

COMPENSATION & EQUITY
Central to our organization is attracting, retaining and engaging the best and brightest by sharing in the success of our organization:

  • Competitive salaries and an annual incentive program
  • 401K matching program with immediate vesting
  • Eligibility for long-term equity incentives upon hire and annually

TIME OFF
We believe it’s important to relax, unwind and enjoy life’s moments:

  • Paid vacation
  • A year-end office closure
  • Observed company holidays
  • Paid sabbatical upon 5 years’ tenure

We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. We take our work very seriously, but we also ensure we’re having fun while doing it. We embrace the freedom to pursue innovation, think creatively, and give back. We care about each other, celebrate our accomplishments, and rise up to encourage our colleagues through challenges. If you think one of these open positions might be a fit, we’d love to hear from you.

Company info
Website
Location
5 Science Park
395 Winchester Ave
New Haven
Connecticut
06511
US

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