Project Leader

Position Title: Project Leader

Position Level: Senior / Executive Director

Reports to: COO

Company Background:

Century Therapeutics is developing novel allogeneic living cell products for oncology that overcome the limitations of current cell therapies. Century's genetically-engineered, universal iPSC-derived immune effector cell products are designed to specifically target hematologic and solid tumor cancers. Our commitment to developing off-the-shelf cell therapies will expand patient access and provide an unparalleled opportunity to advance the course of cancer care.

Century's foundational technology is built on induced pluripotent stem cells (iPSCs) that have unlimited self-renewing capacity. This enables complex cellular engineering to produce controlled cell banks of modified cells that can be expanded and differentiated into desired immune effector cells, which can supply vast amounts of allogeneic, homogeneous therapeutic products. This platform differentiates Century from other approaches that utilize non-renewable donor-derived cells.

Role:

This position reports directly to the Chief Operations Officer. The candidate will lead cross-functional drug development teams through preclinical and clinical phases, focused on the development of Century's novel iPSC-derived allogeneic iNK and iT cell therapies in hematologic and oncology indications, to enable successful global development and commercialization. They will work collaboratively with the project team to develop target profiles and development strategies, and deliver on plans to achieve corporate goals

Responsibilities:

• Leads cross-functional drug development teams through preclinical and clinical phases, focused on the development of NK or T cell therapeutics in hematology and oncology, to enable successful global development and commercialization

o Accountable for project deliverables along with the team

o Responsible for > 1 pipeline project and all indications

• Provides direction and leadership to the project team, including scientific oversight of activities, data review based on key milestones, budget, and planning.

• Partners with the team and other stakeholders to develop vision, product profile, strategy, objectives, go/no go decisions, milestones, risk assessment and mitigation strategies, as well as determining annual budget and investment requirements

• Ability to delve into depth into scientific, medical, development and commercial as needed in partnership with the team

• Leads proposals and assessments at governance committees for the project

• Proactively identifies challenges, risks and prepares team with mitigations to navigate team through technical and program challenges as they arise

• Works hand-in-hand with the Project Manager, coordinates planning and analysis of project deliverables and key decisions.

• Inspires and engenders high performing teams

• Communicates effectively across all functional areas so that deliverables and interdependencies are clear

Qualifications:

• Advanced degree in life sciences or medicine (PhD, MD, MBA or MA/MS)

• 10+ years of pharma or biotech drug development line or matrix management experience with 5+ years leading cross-functional development teams in hematology or oncology, preferably with cell therapy experience, or another advanced therapeutic modality experience

Requirements:

• Demonstrated leadership and decision-making ability

• In-depth knowledge of all phases of drug development including regulatory processes

• Understanding of or willingness to learn allogeneic cell therapy

• Ability to drive CRO KPIs and external vendors in an outsourced clinical model

• Top-tier understanding of project management principles, functions, and processes relevant to drug development

• Highly collaborative and ability to engage and influence team members at all levels. Thrives in team environment.

• Demonstrated ability to successfully engage senior management, and internal and external stakeholders

• Ability to guide the team and make trade-off decisions on program scope, costs and strategy

• Able to comfortably dive into any area of the program, understand business needs, effectively challenge team members, and make decisions based on changing priorities

• High energy, results-oriented, and driven to deliver on the program success

• Able to motivate and develop individual team members and overall team performance

• Proven excellent collaboration, interpersonal, writing, and presentation skills; demonstrated success representing programs to internal and external stakeholders

• Strong initiative and “can do” attitude, and dedicated work ethic