Research Associate II / Senior Research Associate, Analytical & Formulation Development

Employer
Dren Bio
Location
Bay Area
Posted
Nov 08, 2021
Ref
1025
Required Education
Bachelors Degree
Position Type
Full time

About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.

Function:

Analytical & Formulation Development

Level:

Research Associate II / Senior Research Associate

Location:

Redwood City, CA

Reporting Manager:

Director, Analytical & Formulation Development

About the Opportunity:

Dren Bio is seeking a highly motivated individual to support the protein/antibody characterization needs for all discovery and development for the Company’s pipeline programs. The successful candidate will work as a bench scientist in the Analytical & Formulation Development department and contribute to the analytical method development and formulation needs of the company. This position offers excellent potential for contribution and visibility at an early-stage company and opportunities for career development.

Role and Responsibilities:

  • Routinely run HPLC (SE-HPLC), capillary electrophoresis (Reduced and Non-reduced), icIEF, and ELISA based analytical methods for protein/ antibody characterization.
  • Help develop the above methods for all the molecules in Dren’s pipeline.
  • Work closely with colleagues in Process Sciences to ensure timely analytical support for cell line, process, and formulation development.
  • Facilitate the development of SOPs for various analytical methods and the qualification of methods required for technical transfer to CMO/CRO facilities.
  • Maintain and troubleshoot analytical instrumentation, as required.
  • Troubleshoot assay performance, as needed.
  • Document experimental work in electronic lab notebooks, author SOPs, reports.
  • Communicate results in group meetings.

Education, Experience and Qualification Requirements:

  • Bachelors in Biochemistry, Analytical Chemistry or related discipline with 2+ years of experience in the biotechnology industry; Masters in Biochemistry, Analytical Chemistry or related discipline with 0 - 2+ years of experience in the biotechnology industry.

Core Competencies, Knowledge and Skill Requirements:

  • Hands-on knowledge of technical scientific principles for most of the following analytical techniques: HPLC/UPLC (reverse phase, ion exchange, size exclusion), capillary electrophoresis (reduced and non-reduced CE-SDS), charge heterogeneity (icIEF), ELISAs
  • Strong analytical and critical thinking skills with the ability to interpret obtained results/data
  • Highly motivated to learn and support the drug development efforts at Dren Bio
  • Motivated self-starter who can work independently and collaboratively in a dynamic team environment
  • Excellent written and verbal skills
  • Ability to work in a fast-paced environment and the flexibility to align daily work with project needs
  • Must be well organized, have a strong work ethic with attention to details, and diligent in data documentation.

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.