Scientist ll, Cancer Biology

South San Francisco, California
Nov 07, 2021
Required Education
Bachelors Degree
Position Type
Full time
About AbbVie
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Since 2013, AbbVie has expanded its commitment to the San Francisco Bay Area, now represented by three facilities in Redwood City, South San Francisco, Sunnyvale and a future new Bay Area headquarters in South San Francisco. AbbVie employees in the Bay Area drive AbbVie’s research-based, innovation driven missions in healthcare. Specifically, Bay Area employees bring deep scientific expertise and commercial excellence to advance cancer care. Current oncology areas of focus include immuno-oncology, tumor targeting, tumor dependency and precision medicine. With facilities positioned in the heart of the biotechnology industry, we are able to collaborate with the best and brightest minds in oncology.

We are looking for a highly motivated scientist with a broad understanding and experience in tumor cell biology, with a profound capability of understanding molecular mechanisms of driver oncogenes and their translatability into successful areas of cancer therapy. The successful candidate will be expected to conceive and execute novel scientific approaches to achieve R&D project goals in a timely manner and clearly communicate the scientific rationale, methodology and results in written and oral formats.


  • Designing and executing experiments to inform cancer target biology using a variety of cellular/molecular and functional genomics approaches, including CRISPR-mediated cell line engineering, analysis of signaling pathway and characterization of cell death mechanism(s)
  • Utilizing knockdown, knockout, knockin and over-expression of protein for target validation
  • Identifying and validating pharmacodynamic readouts for novel oncology targets
  • Collect, analyze, and summarize data for presentations, reports, publications, and patents
  • Interact cross-functionally and provide scientific leadership on preclinical project teams
  • Maintain an up-to-date understanding of new technologies and relevant scientific advances in tumor dependencies and its roles in cancer from literature and scientific meetings

  • Scientist l: Bachelor’s Degree or equivalent education and typically 10 years of experience, Master’s Degree or equivalent education and typically 8 years of experience, or PhD.
  • Scientist ll: Bachelor’s Degree or equivalent education and typically 12 years of experience, Master’s Degree or equivalent education and typically 10 years of experience, or PhD and typically 4 years of experience.
  • Bachelor’s degree with 7 or more years of relevant experience or MS with 5 or more years of experience either in academic or industry setting
  • Proven track record that demonstrates the ability to design, execute and interpret experiments via publications, external presentations, or patents
  • Hands on experience in lentiviral production and transduction, stable cell line development and CRISPS-cased gene editing
  • Proficient in nucleic acid extraction/purification, qRT-PCR, western blotting/WES, ELISA/MSD, flow cytometry, viability assays and compound screening and other cell and molecular biology techniques
  • Experience with bioinformatic analysis of multi-OMICS data is preferred

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Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.