Senior Research Associate, Histology

Century Therapeutics is developing novel allogeneic living cell products for oncology that overcome the limitations of current cell therapies. Century's genetically-engineered, universal iPSC-derived immune effector cell products are designed to specifically target hematologic and solid tumor cancers. Our commitment to developing off-the-shelf cell therapies will expand patient access and provide an unparalleled opportunity to advance the course of cancer care.

Century's foundational technology is built on induced pluripotent stem cells (iPSCs) that have unlimited self-renewing capacity. This enables complex cellular engineering to produce controlled cell banks of modified cells that can be expanded and differentiated into desired immune effector cells, which can supply vast amounts of allogeneic, homogeneous therapeutic products. This platform differentiates Century from other approaches that utilize non-renewable donor-derived cells.

Role:

The candidate will assume a hands-on role within the histology lab in the Department of Translational Development. Reporting to the Histopathology Senior Scientist, the candidate will perform a variety of tasks, consisting primarily of processing tissue specimens for immunohistochemical stains using previously optimized protocols as well as supporting the optimization of new protocols as the needs arise. Throughout this process the individual will be responsible for the management of the histology area maintaining inventory supplies cleaning and organizing the workstation, disposal biological waste and adherence to all compliance and operational procedures.

Responsibilities:

• Follow SOPs and protocols to conduct histology-based assays for tissue or biomarker detection utilizing specialized equipment. Methods including histochemistry, immunohistochemistry (IHC), multiplex immunofluorescence (mIF) and in-situ hybridization (ISH).
• Analyze the results for documentation and reporting.
• Prepare laboratory reagents and solutions.
• Record work into Benchling electronic lab notebook to maintain records.
• Maintain archived histological slides.
• Performs routine preventative maintenance, cleaning, and minor adjustments on all lab equipment.
• Implement new lab techniques as needed and work collaboratively with the team members to write SOPs and protocols.
• Performs all procedures in a timely manner.
• Assists in the ordering of laboratory supplies to maintain proper inventory.
• Performs computer data entry and sample tracking on complex Laboratory information management system (LIMS) network.
• Performs other duties as assigned.

Qualifications:

• BS or MS degree in cell biology, immunology, molecular biology, or other related fields
• 3 or more years of research experience. Minimum 1-year full time histology laboratory experience in an industry/histo-pathology CRO or academic setting, working with clinical specimens.

Requirements:

• Hands-on experience in histopathological techniques, including tissue processing, embedding, microtome sectioning of FFPE blocks, H&E stain, IHC, and multiplexed IF.
• Excellent writing and verbal communication skills.
• Strong organizational skills, problem-identification and solving skills, ability to work with minimal supervision, and ability to interact well with others.
• Previous experience with automated staining (e.g., Leica BondTM) and scanning platforms is helpful but not essential as full training will be provided.