Senior Research Associate, Drug Substance Process Development

Location
Cambridge, MA
Posted
Nov 05, 2021
Ref
4143898004
Required Education
Bachelors Degree
Position Type
Full time

Omega Therapeutics is a development-stage biotechnology company pioneering the first systematic approach to use mRNA therapeutics as programmable epigenetic medicines by leveraging its OMEGA Epigenomic Programming™ platform. The OMEGA™ platform harnesses the power of epigenetics, the mechanism that controls gene expression and every aspect of an organism's life from cell genesis, growth and differentiation to cell death. The OMEGA platform enables control of fundamental epigenetic processes to correct the root cause of disease by returning aberrant gene expression to a normal range without altering native nucleic acid sequences. Omega’s engineered, modular, and programmable mRNA-encoded epigenetic medicines, Omega Epigenomic Controllers™, target specific intervention points amongst the thousands of  mapped and validated novel DNA-sequence-based epigenomic loci to durably tune single or multiple genes to treat and cure disease through Precision Genomic Control™. Omega is currently advancing a broad pipeline of development candidates spanning a range of disease areas, including oncology, regenerative medicine, multigenic diseases including immunology, and select monogenic diseases.

 About the Role:

Omega Therapeutics, Inc. is seeking a Senior Research Associate to join our Process Development & Analytical Sciences team supporting process development of scalable mRNA synthesis and purification of molecules of interest.  The candidate must be independent and motivated, and able to efficiently advance multiple programs.

As part of the Process Development team, they will work closely with Analytical Development, Formulation Development and Effector Engineering to develop, synthesize, purify, and characterize critical molecules of interest.  They will have a strong understanding of molecular biology and biochemistry concepts, with broad experience in mRNA production, and excellent organizational and documentation skills.  

We are looking for enthusiastic, detail oriented, and highly motivated individuals with a passion for bringing novel medicines to patients and who are comfortable working on a fast-paced scientific team.

Key Responsibilities:

  •  Be part of a team responsible to develop a robust process for scaling up synthesis and purification of mRNA
  • Conduct, troubleshoot, and modify experiments to reach desired goals and develop SOPs
  • Oversees raw materials preparation, buffer preparation and machine maintenance as it pertains to mRNA production and characterization
  • Complete standard analytical procedures on formulations and molecules of interest to ensure the quality of the material prior to further experimentation
  • Working closely with Analytical Development, assist in analytical development for in vitro transcribed mRNA
  • Work independently, as well as, collaborate with colleagues in support of project goals
  • Communicate research and development findings with internal teams
  • Apply efficient work-flows to ensure data and materials are available to internal and external groups in a timely manner
  • Adhere to all laboratory safety requirements and procedures
  • Begin to design and execute experiments through proper DoE method toward improvement and optimization of plasmid and mRNA production processes
  • Define and execute studies to identify critical process parameters through QbD, ensure robust process performances
  • Critically review and analyze data, communicate results, present findings and draft technical reports
  • Support development of standard operating procedures, technology transfer activities and documentation in support of regulatory filings

Required Qualifications:

  • BA/BS in Biochemistry, Molecular Biology, Biomedical Engineering or related discipline with 3-5+ years of laboratory experience OR MS in Biochemistry, Molecular Biology, Biomedical; Engineering or related discipline with relevant experience
  • Experience in process development and production of biomacromolecules such as mRNA, pDNA, siRNA, proteins or viral gene therapy
  • Experience with multiple modes of separations method development including HPLC/UPLC, FPLC, TFF
  • Working knowledge of nucleic acid chemistry, enzymatic and chemical reactions, PCR, plasmid processing, and standard analytical techniques for macromolecules (e.g. electrophoresis, enzyme activity, ELISA, PCR)
  • Able to execute and optimize process SOPs for mRNA and protein production
  • Proficient in Microsoft Office (Excel, Word, Powerpoint); prior experience with electronic laboratory notebooks and inventory systems is preferred
  • Demonstrated creativity and problem-solving skills
  • Excellent communication skills, both oral and written
  • Motivated and curious, experience working with highly technical projects and personnel
  • Demonstrated ability in working with highly skilled teams in a fast paced, entrepreneurial and technical setting
  • Highly adaptable and responsive to technical and business opportunities- comfortable delivering against challenging commitments