Associate Scientist, Oncology

Location
Seattle, WA
Posted
Oct 26, 2021
Ref
2583850
Required Education
Bachelors Degree
Position Type
Full time
Associate Scientist, Oncology
United States - Washington - Seattle

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the company’s five core values. That’s because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible


Gilead's Oncology Research group is seeking a talented and highly motivated biologist to support the discovery and development of innovative cancer treatments for solid tumors. The successful candidate will work within a highly collaborative, dynamic, and fast-paced environment in which they will contribute to multidisciplinary project teams focused on validating and advancing novel and early stage candidate drug targets. Immediate research efforts will be focused on identifying small molecule targeted agents that may be used alone and/or in combination with immunotherapy to treat patient populations with unmet medical need.

Key Responsibilities
  • Independently plan, execute, analyze, and interpret in vitro and ex vivo experiments to support research project goals
  • Contribute to multiple projects simultaneously, working cross-functionally with colleagues from across the research organization (e.g., oncology biology, chemistry, protein therapeutics, high throughput biology, in vivo pharmacology, bioinformatics, genomics, biomarker sciences) and with external CROs.
  • Communicate research objectives, experimental results, and conclusions to project team members and senior staff, delivering key data needed to inform decision making
  • Contribute to preparation of research reports, manuscripts, INDs, and patent filings
  • Proactively evaluate new technologies and develop new assays to accelerate early-stage discovery research and/or enhance understanding of disease mechanisms


Knowledge, Experience and Skills
  • 9+ years of experience with BS degree in a related scientific discipline or 8+ years of experience with MS degree in a related scientific discipline. A work history demonstrating direct participation in biopharmaceutical drug discovery is highly preferred.
  • The successful candidate will demonstrate a broad range of technical skills applicable to the discovery, identification, and validation of novel oncology targets.
  • Extensive skills and experience in human/mouse tissue culture and cell-based experimental model development are essential. Prior work with solid tumor 3D/spheroid or tumor-immune cell co-cultures is an asset.
  • Experience in developing phenotypic and functional assays to characterize tumor cell behavior (e.g., cell proliferation/viability, clonogenic growth, cell death/apoptosis, cell cycle analysis, Incucyte assays) is required.
  • Experience with methods for evaluating gene/protein expression and cell signaling pathways (e.g., RT-qPCR, Nanostring, Western blot, Simple Western, ELISA, MSD, Luminex, reporter-based assays) is required.
  • Experience with techniques for perturbing gene/protein expression and/or function (e.g., RNAi, CRISPR/Cas9, targeted protein degradation, ectopic overexpression, transfection, lentiviral transduction) is highly desired.
  • Experience in evaluating the activity of small-molecule inhibitors and/or biologics in pre-clinical models (e.g., dose response studies, pharmacodynamic assays, anti-tumor efficacy studies) is highly desired.
  • Experience implementing biochemical assays to assess potency of small molecule inhibitors is an asset.
  • Understanding of cancer genomics, synthetic lethality, DNA repair pathways, oncogenic signaling pathways, and mechanisms of primary/acquired resistance to cancer therapies are assets.
  • Candidate must demonstrate strong organizational and time management skills to address rapidly shifting project needs and meet timelines.
  • Candidate must demonstrate the ability to independently prepare and deliver clear and concise data presentations at group meetings.

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

Following extensive monitoring, research, consideration of business implications and advice from internal and external experts, Gilead has made the decision to require all U.S. employees and contractors to receive the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.

For more information about equal employment opportunity protections, please view the ‘EEO is the Law' poster.

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