Bioinformatician / Informatics Specialist

Bethesda, Maryland
Oct 19, 2021
Required Education
Bachelors Degree
Position Type
Full time

The National Library of Medicine (NLM) at the National Institutes of Health (NIH) offers an intellectually stimulating environment where the world's top scientists, skilled software developers, and others work together to solve challenging problems and literally help to accelerate cures for diseases! NLM is the world’s premier biomedical library, hosting over six million daily users that seek providing over 6 million users each day with research, clinical, genetic, and other information that directly impacts biomedical research and public health. NLM’s wide range of applications, platforms (node, python, Django, C++, you name it) and environments (big data [petabytes], machine learning, multiple clouds) serve more users than almost any other US Government Agency, according to


MSC is seeking multiple Bioinformaticians / Informatics Specialists to join our NLM team; position level (Junior through Senior) is commensurate with experience. In this role, you will apply your informatics expertise to build and improve scientific tools for discovery.

Duties & Responsibilities
  • Provide high level expertise in the application of technology to Medical Informatics, Public Health Informatics, statistics, biostatistics, mathematics, and/or other areas of interest to government health organizations.
  • Develop computational infrastructure to analyze and provide access to data from genome-wide
  • association studies, high-throughput sequencing, expression arrays and other sources.
  • Effectively work with a team in a production environment and communicate with NLM biologists and programmers, as well as scientists from the extramural community.
  • Support the coordination of data intake, data flow and data distribution for special projects
  • involving subject areas in genomics, genetics, clinical trial data, and chemical structure data.
  • Coordinate and contribute throughout the project lifecycle: requirements definition, design, development, problem diagnosis and resolution, development, and enhancement of system and application software as well as support for various scientific and programming services.
  • Formulate statistical and mathematical approaches to address scientific questions proposed by NIH biologists and researchers.
  • Support the intake and processing of data submissions for large scale studies in genomics and genotyping, including high-throughput sequence data.
  • Support the development of sequence analysis software, e.g., sequence alignment.
  • Apply IT expertise – including information retrieval technology, decision science, web technology, data mining, expert systems, and networking – to public health science and education.
  • Develop computational tools for effective and efficient analysis of large-scale genomic data, including sequence-based, structure-based, array-based, and proteomic data.
  • Support and/or enhance the usability and design of databases, search services, and other software features using document markup language (XML, HTML) and JATS format for scientific articles and information retrieval methodologies (e.g., machine learning and other AI and text).
  • Contribute to the design of systems to incorporate quality assurance workflows.
  • Write robust documentation in a timely fashion using plain language.
  • Master’s degree in Bioinformatics, Biostatistics, Data Sciences, or a closely related field or equivalent experience
  • Professional experience in Bioinformatics, Biostatistics, or Data Sciences within an agile research and development environment
  • Proficiency in R and/or Python applied in Unix/Linux environments
  • Skilled in creating, modifying, and maintaining Unix scripts (shell/perl/python) to perform database management and analysis in parallel
  • Working knowledge of major public bioinformatics databases and tools and experience using bioinformatics software packages, such as MATLAB, STAR, BWA, DESEQ2, Bioconductor, GSEA, samtools, etc.
  • Ability to adapt in a dynamic work environment and work cooperatively with team members and clients from a broad range of disciplines and subject-level expertise
  • Strong communication skills, both written and verbal, regarding both technical concepts and project management
  • Ability to obtain and maintain a Public Trust Clearance
  • Previous experience supporting the NIH is a plus.


Due to our contractual requirements and federal orders, including an Executive Order from the White House and an emergency regulation from the Centers for Medicare & Medicaid Services (CMS), the position for which you are applying requires that you provide proof of your vaccination status. If you are unable to receive the COVID-19 vaccine for medical reasons or because of a sincerely held religious belief, you may request an exemption from the vaccination requirement which shall be reviewed after the submission of requested documentation. If an accommodation is granted, the conditions may include weekly testing and masking. All Guidehouse employees also agree to follow any additional health and safety mitigation policies that may be required in the workplace.