Site Supply Chain Senior Manager

Location
Amsterdam
Posted
Oct 18, 2021
Required Education
Bachelors Degree
Position Type
Full time

Neogene Therapeutics is a pre-clinical stage biotechnology company aiming to change the paradigm of treatment for solid cancers. Our mission is to provide cancer patients with T cell therapies targeting mutated proteins called neo-antigens, which are present on cancer cells as a consequence of DNA mutations. Neogene is developing novel technologies to enable the engineering of ‘designer T cells’ with neo-antigen specificities that display an optimized ability to seek and destroy cancer cells.

We are seeking a highly motivated individual for the role of Site Supply Chain Sr Manager.  The Site Supply Chain Sr Manager is responsible for the setup, management, and evolution of the overall supply chain in the TCR Selection process and facility, including materials availability, production scheduling, warehouse receiving, storage, and shipping.  The TCR selection process is a critical step in Neogene’s neoantigen-based personalized cell therapy process, requiring complex coordination of materials, data, and operations.  This role is highly cross-functional, working with Process Development, Quality, Manufacturing, and Research, and reports to the Head of Supply Chain.

Responsibilities include, but are not limited to:

Materials Planning
  • Ensure raw material availability for site TCR selection production requirements via material planning and purchasing, oversight of vendor-managed inventory, and oversight of time-sensitive patient-specific data to suppliers/CDMOs in exchange for patient-specific processing materials
  • Create and maintain purchase orders
  • Set up and oversee vendor-managed inventory
  • Communicate regularly with suppliers/CDMOs to ensure material orders are filled and delivered as expected. This includes coordinating the transfer of personalized, patient-specific data and materials from suppliers/CDMOs used in the process.
  • Determine inventory targets, monitor and manage inventory on hand to ensure released status and availability.
  • Manage and escalate material supply risks to internal stakeholders. Collaborate cross-functionally to develop and execute mitigation plans.
  • Support new material qualification efforts, tech transfer projects, and process improvements
  • Provide regular forecasts to suppliers to ensure medium to long term supply.
  • Support the start up and evolution of technology and master data capabilities as the planning and inventory management process matures.
Production Scheduling
  • Collaborate with process development leads to develop a scheduling process based upon clinical trial screening/enrollment requirements, employed capacity (staffing levels), unit operation requirements.
  • Manage site capacity assumptions and support decision making on scaling operations as clinical trials advance.
  • Schedule patients to be screened in the TCR selection facility for eligibility in clinical trials.
  • Support the development, implementation, and ongoing execution of product traceability processes and solutions to manage patient flow through the facility and prevent mix-up of patient-specific materials.
Warehouse and Logistics Operations
  • Develop processes for and manage the receipt, storage, picking, and dispensing of raw material inventory and patient biopsy and blood specimens used in TCR selection.
  • Develop processes and manage ad hoc outbound shipments from the facility.
  • Book and monitor shipments from critical suppliers providing personalized materials used in the TCR selection process.
  • Be a local contact and manage relationships with local logistics service providers.

Requirements:

  • 8+ Years with BS/BA, or 6+ Years with MS/MA or MBA
  • Direct experience and working knowledge in planning, procurement, site scheduling, warehouse, and/or materials planning/procurement.
  • Direct experience and working knowledge in the pharmaceutical or biotech industry, cell therapy preferred.
  • Experience working in a manufacturing or service laboratory environment.
  • Excellent interpersonal, written and verbal communicator across organizational levels and functions in this collaborative work environment.
  • Develops solutions with creativity and innovative approaches.
  • Comfortable in a fast-paced, dynamic, and highly fluid company environment with minimal direction and able to adjust workload based upon changing priorities.
  • Organized and attentive to detail
  • Analytical, with advanced Excel skills
  • ERP and Planning System experience
  • 10% travel may occasionally be required.
  • Cell therapy experience preferred
  • Knowledgeable with cGxP as well as regulatory regulations and compliance requirements for cell therapy and pharmaceutical industry
  • Able to express ideas and present information effectively to leadership, within team functions, and with external partners
  • Ability to think critically with demonstrated troubleshooting and analytical skills
  • Contributes to the development of new concepts, techniques, and standards.
  • Considered expert in own area the organization.
  • Develop solutions to complex problems which require the regular use of ingenuity and innovation.
  • Ensures solutions are consistent with organization objectives.
  • Work is performed without appreciable direction.
  • Exercises some latitude in determining objectives and approaches to assignment
  • Accomplishes results through lower-level subordinate supervisors/leads or through experienced exempt employees who exercise significant latitude and independence in their assignments.
  • Provides direction to subordinates based on general policies and management guidance.
  • Interprets and executes policies and procedures that typically affect subordinate organizational units.
  • Recommends modifications to operating policies.

We offer the opportunity to join a highly dynamic growth-stage biotech company. You can expect a collaborative environment created by a team with deep scientific expertise and an industrial track-record in T cell therapies. We value pro-active team-players who pursue their goals with dedication, endurance and a daring mindset. If you share our commitment to make a difference to patients in need, we can provide a unique opportunity to be a major contributor to the success of a well-positioned, well-financed growth-stage biotechnology company.