Scientist, DMPK

Location
Cambridge, MA
Posted
Oct 13, 2021
Hotbed
Genetown
Required Education
Bachelors Degree
Position Type
Full time
JOB TITLEScientist, DMPK

LocationCambridge, MA

Company OverviewOrum Therapeutics is a private biotech company located in Daejeon, Korea, and Cambridge, Massachusetts. We are developing a novel class of therapeutics to bring new medicines to patients with unmet medical needs. Orum leverages its proprietary antibody, conjugation, and medicinal chemistry platforms to inhibit or degrade intracellular target proteins. We are advancing our first set of oncology candidates toward preclinical development.  

The RoleOrum Therapeutics is seeking a DMPK scientist who will be primarily responsible to deliver a quantitative and mechanistic understanding of PK/PD/efficacy relationships to support project teams from early discovery through early clinical development.In addition, the individual will be involved in the design, execution, analysis, interpretation and communication of pharmacokinetics (PK) and absorption, distribution, metabolism, and excretion (ADME) studies of to support drug development from early discovery through preclinical and clinical development. The individual will serve as DMPK project representative to coordinate and lead all nonclinical DMPK activities on programs from the research phase through development. An individual with in-depth knowledge and expertise in PK/PD modeling and simulation and ADME would be essential.

Principal Duties and Responsibilities
  • Deliver a quantitative and mechanistic understanding of PK/PD/efficacy relationships to support drug discovery and development teams

  • Design and execute preclinical studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of drug candidates

  • Represent DMPK as the subject matter expert to project teams, develop and drive DMPK and PK/PD strategy for drug discovery projects

  • Responsible for the analysis, interpretation, integration and reporting of preclinical DMPK data generated both internally and with external vendors

  • Participate in the management of CROs in the conduct of in vitro/in vivo ADME studies

  • Partner with and support all other relevant departments

  • Qualifications
  • PhD. in Pharmacokinetics, Pharmacology, Pharmaceutics or other relevant field with 5 years of experience in the biopharmaceutical industry preferred, or MS/BS with 5 years' industry experience, including modeling and simulation experience

  • Conceptual fluency with modeling, and in depth hands-on modeling experience (e.g. using WinNonlin Phoenix, MATLAB/Simbiology, PK Sim, Simcyp, or, background using NONMEM to develop PK/PD models)

  • Strong knowledge of drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamic and bioanalytical principles is required

  • Experience with biologics desirable but not required

  • Strong communication (verbal and written) and presentation skills required

  • Excellent interpersonal skills and ability to represent DMPK in a team environment are essential

  • Please send your resume and cover letter to jobs@orumrx.com to apply

    (Title field: Full Name_DMPK)

    Orum is committed to a workplace in which diversity of people and ideas are valued and welcomed. Orum provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.