Scientist, Analytical Science

JOB TITLE

Scientist, Analytical Science

Location

Cambridge, MA

Company Overview

Orum Therapeutics is a global biotech pioneering the precise delivery of targeted protein degraders and other next generation ADC payloads to improve the treatment of cancer. The company’s neoDegraders are novel, proprietary payloads for targeted protein degradation and its Antibody neoDegrader Conjugate (AnDC) platform generates first-in-class antibody drug conjugates. The first therapeutic candidates from the AnDC platform are in development for the treatment of solid tumors and hematologic cancers. Orum announced the close of a $84 million Series B financing . The first two oncology assets are expecting IND filing in mid - 2022 and Q1 2023. Orum is located in Cambridge, Massachusetts, U.S., and Daejeon, South Korea. For more information, visit www.orumrx.com

 

The Role

Orum Therapeutics is seeking to expand our in-house analytical capabilities to help advance quality compounds toward the clinic. The successful candidate will have a strong background in LC-MS antibody/protein characterization or bioanalytical quantitation and a passion for driving high-impact projects in the anti-cancer drug discovery space. He/she will conduct bench-based research focused on sample preparation, LC-MS and HPLC analytical characterization/quantitation for ADC, Antibody, small molecule drug, data analysis and report within a dynamic, enthusiastic, highly interdisciplinary and collaborative team.  

Responsibilities

Perform LC-MS characterization of ADC, antibody and small molecule drug to support Chemistry discovery and production including but not limited to: intact mass analysis, deglycosylation and reduction LC-MS, DAR measurement, peptide mapping, PTM profiling, native MS, structural characterization for small molecule drug.

Identify metabolites of ADC from in vivo or in vitro samples with LC-MS technology

Utilize LC-MS to perform non-GLP bioanalytical quantitation method development, qualification and sample analysis for antibody, small molecule drug, and corresponding metabolite

Characterize ADC and antibody using HPLC methodology (SEC, HIC, IEX, RP etc), plus method development

Instrument operation, maintenance and troubleshooting for Thermo Vanquish UHPLC-Orbitrap MS, Waters Acquity UPLC-SQD MS, and Agilent HPLC

Prepare samples to be tested by LC-MS and LC-MSMS from various sources, i.e., purified protein products, biological matrix (plasma, serum and tissues, etc)

Learn and apply bioconjugation to support discovery research as needed

Present written and oral reports to multidisciplinary team

Enter all data into electronic laboratory notebooks and database on a daily basis, generate weekly summary reports for management review

Assist in managing outsourced work from characterization to bioanalysis at CROs

Identify and integrate technologies that improve or expand the ability to LC-MS and HPLC analysis by working with teammates, collaborators, vendors, and staying abreast of the literature

Contribute to the build-out and upkeep of an expanding laboratory through maintaining shared equipment, assisting with general laboratory housekeeping, and developing processes for improving workflow efficiency

Requirements and Qualifications

Ph. D in Chemistry or Biochemistry or a relevant scientific discipline with 1+ year experience (postdoc or industry) for therapeutic protein LC-MS analysis, Master with 3+ year of industry experience

Essential to possess technical expertise in the LC-MS analysis of proteins, which may range from protein characterization, protein bioanalytical quantitation and proteomics.

Hands-on experiences are necessary, including sample preparation (deglycosylation, reduction, and in-solution/in-gel digestion), LC-MS operation, basic maintenance and troubleshooting, HPLC (SEC, HIC, IEX, RP etc)

Skills are plus as follows: extraction and enrichment techniques (Affinity Capture, SPE, Protein Precipitation), CE-SDS, cIEF, DLS, DSC, SDS-PAGE etc; 

Willingness to learn and apply bioconjugation to support discovery research as needed

A track record of innovation and scientific rigor, strong problem solving and troubleshooting skills, and ability to contribute constructively to discussions

Goal oriented, organized, capable of prioritizing and working on multiple projects, and able to help others

Good verbal and written communication skills

Enthusiasm for collaborating with multidisciplinary teams of chemists, protein engineers, and biologists

Proficiency with operating common laboratory equipment and maintaining laboratory infrastructure

 

 Please send your resume and cover letter to jobs@orumrx.com to apply

(Title field: Full Name_Analytical Scientist)

 

Orum is committed to a workplace in which diversity of people and ideas are valued and welcomed. Orum provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.