Senior Principal Scientist, Predictive Sciences

Redwood City, California
Oct 09, 2021
Required Education
Position Type
Full time

At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science.In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Senior Principal Scientist, Early Development Predictive Sciences

We are seeking an innovative scientist to join our Early Development Informatics and Predictive Sciences team. This group of computational biologists is responsible for advancing Bristol-Myers Squibbs industry-leading Early Clinical Development pipeline through the strategic application of state-of-the-art computational approaches. The scientists in this group are responsible for the design of experiments and analysis of a wide array of datasets in both the pre-clinical and clinical space to develop patient enrichment strategies, discover novel biomarkers and diagnostics, and guide drug development decisions. The group interacts with and influences all aspects of R&D at BMS, from early discovery through late-stage development. This scientist can work in any of the following locations: Seattle WA, Redwood City CA, San Diego CA, Cambridge MA, Lawrenceville NJ, or Summit, NJ.

Informatics and Predictive Sciences (IPS) has a mission to drive predictive informatics research across BMS. The role of IPS encompasses a broad range of computational research, from cutting-edge bioinformatics to discover new therapeutic targets to applied machine learning in order to optimize clinical trial design and predict patient outcomes. The Early Development Predictive Science team focuses on computational research to progress BMS' Early Development clinical pipeline.


This individual would be responsible for leading the analysis and integration of clinical and translational data from immune-oncology and cell therapy clinical trials, in collaboration with Early Clinical Development and Translational Research. The scientist would analyze datasets spanning RNASeq, WES, single-cell sequencing, immunophenotyping and cytokines, with the goal of guiding early-stage clinical development of the BMS pipeline, informing trial design, and enabling patient enrichment strategies. They would develop and drive collaborations with other bioinformaticians, statisticians, biologists, and clinicians to design and execute computational analysis to impact our Early Phase Clinical Development portfolio.


  • Ph.D. in bioinformatics, molecular biology, statistics, physics, genetics, or similar area
  • 7+ years of relevant experience
  • Extensive background in Oncology or Immunology and experience working with clinical trial data in a drug development setting
  • Broad experience with data generated by one or more high-throughput molecular assays: next-generation sequencing, metabolomics, flow cytometry, mass spectrometry proteomics, etc.
  • Strong experience in the use of a high-level programming language such as R, Python or MATLAB for complex data analysis and reproducible research practices
  • Excellent problem-solving and collaboration skills, and rigorous and creative thinking
  • Exceptionally strong communication, data presentation and visualization skills
  • Demonstrated ability to derive impactful biological insight from computational analysis of clinical trial data
  • Ability to independently develop understanding of key program questions and formulate and execute analysis plans to address these questions
  • Capability to establish strong working relationships across and within organization

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

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