Scientist, Gene Editing Platform Development

Location
Cambridge, MA
Posted
Oct 08, 2021
Ref
R232
Hotbed
Genetown
Required Education
Bachelors Degree
Position Type
Full time

Why Join Intellia? 

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. 

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. 

We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.   

How you will Achieve More with Intellia

We are looking for a Scientist to join our energetic and exciting cross-functional team. You will be responsible for helping drive emerging gene-editing technologies towards human therapeutics. You will evaluate new technologies and approaches to support Intellia’s Gene Editing Platform Development. Additional role responsibilities include: 

  • Design, execute and troubleshoot high throughput experiments to optimize gene editing efficiency in different mammalian immortal cell lines and primary cells via different delivery methods (Lentivirus, AAV, Lipid nanoparticles, etc.) 

  • Perform experiments using multiple instruments to measure mRNA and protein expression (RT-PCR, ELISA, MSD, Flow-cytometry, etc.) and/or genome integrity (digital droplet PCR, Next-generation sequencing, etc.) 

  • Act as a liaison and collaborate in a matrixed organization to optimize gene editing efficiency in different animal models  

  • Document results in a timely manner in electronic notebooks and present data internally and with external collaborators.  

  • Analyze and synthesize results to assess future directions 

 

About You

Do you describe yourself as high-energy and goal-driven? Our ideal candidate will have extensive experience with different CRISPR-based gene-editing technologies. Expertise with a broad spectrum of molecular biology, cell biology, and biochemical methodologies is also required. Additional role requirements include: 

  • Organized, driven self-starter with demonstrated problem-solving skills and the ability to work effectively within a broader cross-functional team 

  • Ph.D. in Biochemistry, Biophysics or Cellular and Molecular biology with 0-2 years of post-PhD experience. Strong candidates with Bachelors (6-8 years) or Masters (4-6 years) in related disciplines will also be considered.  

  • Extensive knowledge of the CRISPR landscape and experience in mammalian genome editing with CRISPR/Cas9 or similar technologies. 

  • Experience with rational design and/or directed evolution of proteins and/or nucleic acids 

 

Meet your future team 

The Gene Editing Platform Development team, within the Platform Innovation function, is a cohesive group of fun and energetic individuals. We have a common goal of making a difference by developing new and improved CRISPR-based gene editing tools for curative human therapeutics. You will report directly to the Associate Director, Platform Innovation. This hiring manager leads/co-leads engineering efforts geared towards expanding Intellia’s gene-editing toolbox to potentially unlock currently inaccessible disease indications. Given the breadth of activities within this team, the candidate will have the opportunity to explore both new and established projects across Intellia’s in vivo and ex vivo platforms and programs.   

 

The team is currently working mostly onsite to execute workflows in a wet-lab environment. Therefore, we require the candidate to be currently local to Cambridge MA, or open to relocating.  While much of the day-to-day operations require wet-lab work, our team is focused on building not just technical expertise but fostering an environment for the growth of scientists interested in a career in biotech and chemistry.  If you join our team, you can expect to join a hardworking and collaborative environment. We look forward to fostering your skills, learning from your experiences, and building a larger team that will make a difference in patient’s lives. 

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EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.